Results 61 to 70 of about 5,699,590 (286)
Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects. [PDF]
, 2019 Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific gene networks results in birth defects, which affect 5% of live births.
de Soysa, T Yvanka +9 more
core
Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells. [PDF]
, 2019 Cellular products derived from the activity of DNA, RNA, and protein synthesis collectively control cell identity and function. Yet there is little information on how these three biosynthesis activities are coordinated during transient and sparse ...
Baskar, Reema +3 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Data Exploration, Quality Control and Testing in Single-Cell qPCR-Based Gene Expression Experiments [PDF]
, 2012 Cell populations are never truly homogeneous; individual cells exist in biochemical states that define functional differences between them. New technology based on microfluidic arrays combined with multiplexed quantitative polymerase chain reactions ...
Chattopadyay, Pratip K. +7 more
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
On the Performance Gain of NOMA over OMA in Uplink Communication Systems
, 2019 In this paper, we investigate and reveal the ergodic sum-rate gain (ESG) of non-orthogonal multiple access (NOMA) over orthogonal multiple access (OMA) in uplink cellular communication systems. A base station equipped with a single-antenna, with multiple
Hanzo, Lajos +4 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman +8 more
wiley +1 more source
Looking Back: Single-Cell Analysis [PDF]
Cell Stem Cell, 2017 Over the past few years, burgeoning single-cell analyses platforms have unlocked access to previously unobtainable biological information about stem cell populations. For our tenth anniversary, we asked authors that cited a selection of our most popular papers in this area about how these studies influenced their work and the field.
openaire +2 more sources
Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul +13 more
wiley +1 more source