Results 81 to 90 of about 4,724,822 (306)

Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages

, 2017
Stem cell engineering and grafting of mesencephalic dopamine (mesDA) neurons is a promising strategy for brain repair in Parkinson's disease (PD). Refinement of differentiation protocols to optimize this approach will require deeper understanding of ...
Perlmann, Thomas,, Storvall, Helena,, Gillberg, L, Perlmann, Thomas., Joodmardi, Eliza, Kirkeby, A, Gillberg, Linda,, Parmar, Malin,, Kirkeby, Agnete, Perlmann, Thomas, Lahti, Laura,, Sandberg, Rickard,, Nolbrant, Sara, Dahl, Lina,, Bjorklund, AK, Kee, N,, Storvall, H, Dahl, L, Kee, Nigel, Lahti, L, Björklund, Åsa K., Volakakis, Nikolaos, Kee, Nigel,, Dahl, Lina, Joodmardi, E, Parmar, Malin, Volakakis, N, Björklund, Åsa K.,, Bjoerklund, Aasa K., Joodmardi, Eliza,, Gillberg, Linda, Lahti, Laura, Storvall, Helena, Volakakis, Nikolaos,, Nolbrant, Sara,, Sandberg, Rickard, Nolbrant, S, Kirkeby, Agnete,   +37 more
core   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Single Cell Isolation from Surgically Resected Tissue Via Mechanical Dissociation Using TissueGrinder

19Primary cells form the basis of modern-day in vitro research analysis tools. Many conventional procedures for generating single-cell suspensions from solid tissue are neither robust nor reproducible.
Scheuermann, Stefan, Pallavi, Prama
core   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Deep Learning in Single-cell Analysis

ACM Transactions on Intelligent Systems and Technology
Single-cell technologies are revolutionizing the entire field of biology. The large volumes of data generated by single-cell technologies are high dimensional, sparse, and heterogeneous and have complicated dependency structures, making analyses using conventional machine learning approaches challenging and impractical.
Dylan Molho, Jiayuan Ding, Wenzhuo Tang, Zhaoheng Li, Hongzhi Wen, Yixin Wang 0003, Julian Venegas, Wei Jin 0009, Renming Liu, Runze Su, Patrick Danaher, Robert Yang, Yu Leo Lei, Yuying Xie 0001, Jiliang Tang   +14 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst

iMeta
The rapid advancement of multi‐omics single‐cell technologies has significantly enhanced our ability to investigate complex biological systems at unprecedented resolution.
Lu Pan, Bufu Tang, Xuan Zhang, Paolo Parini, Roman Tremmel, Joseph Loscalzo, Volker M. Lauschke, Bradley A. Maron, Paola Paci, Ingemar Ernberg, Nguan Soon Tan, Ákos Végvári, Zehuan Liao, Sundararaman Rengarajan, Roman Zubarev, Yuxuan Fan, Xu Zheng, Xinyue Jian, Ren Sheng, Zhenning Wang, Xuexin Li   +20 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Single-Cell-Derived Tumor-Sphere Formation and Drug-Resistance Assay Using an Integrated Microfluidics

, 2019
Considerable evidence points to cancer stem-like cells (CSCs) as responsible for promoting progression, metastasis, and drug resistance. Without damage to the cell biological properties, single-cell-derived tumor-sphere is encouraging options for CSCs ...
Jing Ding, Long Pang (457760), Long Pang, Jianglin Fan (448849), Yuxin Ge, Yuxin Ge (5988779), Shih-Kang Fan (733610), Jianglin Fan, Shih-Kang Fan, Jing Ding (32381)   +9 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source