Results 151 to 160 of about 5,714,705 (321)

scPair: Boosting single cell multimodal analysis by leveraging implicit feature selection and single cell atlases

Nature Communications
Multimodal single-cell assays profile multiple sets of features in the same cells and are widely used for identifying and mapping cell states between chromatin and mRNA and linking regulatory elements to target genes.
Hongru Hu, Gerald Quon
doaj   +1 more source

Single Cell Detection and Analysis with Asynchronous Rotation of Driven Magnetic Microspheres [PDF]

, 2009
Brandon H. McNaughton, Päivö Kinnunen, Rodney R. Agayan, Ron G. Smith, Alan Hunt, Raoul Kopelman, Roy Clarke   +6 more
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Single-cell analysis of influenza A virus replication : sources of cell-to-cell heterogeneity and discoverey of a novel type of defective interfering particle

, 2019
Sascha Young Kupke
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Single-Cell Transcriptional Analysis Reveals the Mechanism of AZD6738 in HCC Immunotherapy via EZH2 Targeting

Drug Design, Development and Therapy
Ren-peng Li,1– 3,* Guo-zhi Wu,1– 3,* Xi-dong Fang,1– 3,* Wen-wen Yang,1– 3 Hui-yun Zhang,1– 3 Han-xun Yue,1– 3 Ya Zheng,2,3 Yu-ping Wang,2,3 Yong-ning Zhou2,3 1The First Clinical Medical College, Lanzhou University, Lanzhou, People’s Republic
Li RP, Wu GZ, Fang XD, Yang WW, Zhang HY, Yue HX, Zheng Y, Wang YP, Zhou YN   +8 more
doaj  

Bulk and Single-Cell Transcriptome Analysis Reveal Shared Key Genes and Patterns of Immune Dysregulation in Sepsis and Systemic Lupus Erythematosus [PDF]

, 2023
Xuehuan Wen, Songjie Bai, Kai Zhang, Shumin Li, Jiahui Li, Jie Yang, Qing Yu, Lanxin Cao, Zhijian Cai, Gensheng Zhang   +9 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Single-Cell Analysis Reveals Aspirin Restores Intervertebral Disc Integrity via Ferroptosis Regulation

Journal of Inflammation Research
Haiyun Niu,1 Hao Qi,2 Peng Zhang,2 Hongyu Meng,3 Ning Liu,3 Di Zhang2 1Orthopedics Department of Joint Surgery, Hebei Medical University Third Hospital, Shijiazhuang City, Hebei Province, People’s Republic of China; 2Orthopedics Department of Spine ...
Niu H, Qi H, Zhang P, Meng H, Liu N, Zhang D   +5 more
doaj  

Supplementary Figure S11 from Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients [PDF]

, 2023
Tina Sarén, Mohanraj Ramachandran, Gustav Gammelgård, Tanja Lövgren, Claudio Mirabello, Åsa K. Björklund, Kristina Wikström, Jamileh Hashemi, Eva Freyhult, Håkan Åhlström, Rose‐Marie Amini, Hans Hagberg, Angelica Loskog, Gunilla Enblad, Magnus Essand   +14 more
openalex   +1 more source