Results 241 to 250 of about 5,522,894 (323)

Target Screening and Single Cell Analysis of Diabetic Retinopathy and Hepatocarcinoma. [PDF]

J Cell Mol Med
Shao Y, Duan B, Li H, Li X, Peng S, Zheng H, You Z.   +6 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Two subsets of regulatory CD8⁺ T cells with differential transcriptome revealed by single cell analysis. [PDF]

iScience
Sérazin C, Dugast L, Flippe L, Streitz M, Wendering DJ, Schlickeiser S, Heinrich F, Durek P, Guerra GM, Lehmann K, Mashreghi MF, Wajant H, Volk HD, Anegon I, David L, Bézie S, Guillonneau C.   +16 more
europepmc   +1 more source

Single Cell Ras-GTP Analysis Reveals Altered Ras Activity in a Subpopulation of Neurofibroma Schwann Cells but Not Fibroblasts

, 2000
Larry S. Sherman, Radhika P. Atit, Thorsten Rosenbaum, Adrienne D. Cox, Nancy Ratner   +4 more
openalex   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Uncovering potential biomarkers of endometriosis: transcriptomic and single-cell analysis. [PDF]

Front Med (Lausanne)
Liu Y, Gao G, Tian W, Lv Q, Liu D, Li C.
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Targeted screening and single-cell analysis of genetic variants in melanoma using Mendelian randomization. [PDF]

Discov Oncol
Li S, Zhang K, Zhang G, Shi M, Yin X, Wang B.   +5 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Single-cell analysis of gene regulatory networks in the mammary glands of P4HA1-knockout mice. [PDF]

PLoS Genet
Gupta A, Huang L, Liu J, Chen K, Xu R, Wu W.   +5 more
europepmc   +1 more source