Results 241 to 250 of about 9,923,505 (317)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Immunoregulatory Roles of Tumor-Originated Pericytes Identified by Single-Cell Analysis in Glioblastoma. [PDF]

Adv Sci (Weinh)
Chu C, Li F, Zhang Z, Zhu Q, Yan H, Cheng M, Wang H, Cheng L, Zhang Z, Yu X, Man J, Wang W, Li D, Bian XW, Wu HB, Zhang A, Zhou W.   +16 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcome. [PDF]

Cell Rep Med
Näsiaho J, Nissi L, Ventelä S, Irjala H, Salmi M.   +4 more
europepmc   +1 more source

Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation.

Cell, 2018
Jason D. Buenrostro, Jason D. Buenrostro, M. Corces, Caleb A. Lareau, Caleb A. Lareau, Beijing Wu, Alicia N. Schep, Martin J. Aryee, Martin J. Aryee, R. Majeti, Howard Y. Chang, W. Greenleaf   +11 more
semanticscholar   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Three-dimensional forward-scattering imaging flow cytometry system for single-cell analysis. [PDF]

APL Photonics
Zhou M, Zhao J, Chen X, Zhang Z, Lai Z, Zhou Z, de la Zerda A, Lo YH.   +7 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Integrative Single-Cell Analysis Reveals Targetable Vacuole Membrane Protein 1-Mediated Mechanism of Tumor Angiogenesis in Glioblastoma. [PDF]

MedComm (2020)
Jin L, Chen B, Liao J, Guo W, Zhu Z, Ali S, Leung GK, Wang P, Kiang KM.   +8 more
europepmc   +1 more source