Results 291 to 300 of about 763,272 (322)

Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood-brain barrier and interacts with amyloid β. [PDF]

MAbs
Faresjö R, Sjöström EO, Dallas T, Berglund MM, Eriksson J, Sehlin D, Syvänen S.   +6 more
europepmc   +1 more source

Antigen-targeting strategies using single-domain antibody fragments

, 2017
João N. Duarte
openalex   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

eLife Assessment: Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

Dominique Soldati‐Favre
openalex   +1 more source

A Phase 1 Single-Ascending-Dose Trial in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravenous PNT001, a Novel Mid-domain Tau Antibody Targeting cis-pT231 Tau

W Luca, Kelly Foster, K. E. McClure, Michael K. Ahlijanian, Martin R. Jefson   +4 more
openalex   +1 more source

A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity. [PDF]

Acta Pharmacol Sin
Zhu XY, Li QX, Kong Y, Huang KK, Wang G, Wang YJ, Lu J, Hua GQ, Wu YL, Ying TL.   +9 more
europepmc   +1 more source

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Single-domain antibodies applied as antiviral immunotherapeutics

Journal of Virological Methods, 2023
Viral infections have been the cause of high mortality rates throughout different periods in history. Over the last two decades, outbreaks caused by zoonotic diseases and transmitted by arboviruses have had a significant impact on human health. The emergence of viral infections in different parts of the world encourages the search for new inputs to ...
Nidiane Dantas Reis, Prado, Nairo, Brilhante-Da-Silva, Rosa Maria Oliveira, Sousa, Michelle Suelen da Silva, Morais, Sibele Andrade, Roberto, Marcos Barros, Luiz, Livia Coelho de, Assis, Anna Carolina M, Marinho, Luiz Felipe Lemes de, Araujo, Rafael de Souza, Pontes, Rodrigo Guerino, Stabeli, Carla Freire Celedonio, Fernandes, Soraya Dos Santos, Pereira   +12 more
openaire   +2 more sources

Engineering pH-Sensitive Single-Domain Antibodies

2022
There is increasing interest in expanding an antibody beyond high affinity and specificity. One such feature is custom regulation of the binding event, such as pH-dependent control. Here, we provide a methodology for generating single-domain antibodies (sdAbs) that bind their antigen in a pH-dependent fashion.
Tosha M, Laughlin, James R, Horn
openaire   +2 more sources

Single-domain antibodies

2009
The antigen-binding entity of an antibody, reduced in size to one single domain, is referred to as a "single-domain antibody". Various strategies have been explored with variable success to arrive at functional sinlge-domain antibodies. The potential of single-domain antibodies, as research tools or in medicine, is reflected by the three companies ...
Muyldermans, Serge, Hassanzadeh Ghassabeh, Gholamreza, Saerens, Dirk   +2 more
openaire   +3 more sources

Nanobodies: Natural Single-Domain Antibodies

Annual Review of Biochemistry, 2013
Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains.
openaire   +3 more sources