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From Whole Monoclonal Antibodies to Single Domain Antibodies: Think Small
2012The development of therapeutic monoclonal antibodies over the last 35 years has led to the emergence of a new class of useful therapeutic molecules. These "first generation" antibodies have been obtained thanks to the conjugated and huge efforts of both academic and biotech researchers.
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
exaly
Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody
Cell, 2022Cheng Li, Yan-Ning Qian, Qiyu Mao
exaly
Nanobody affinity improvement: Directed evolution of the anti-ochratoxin A single domain antibody
International Journal of Biological Macromolecules, 2020Qi Chen, Zhichang Sun, Chenghui Zhang
exaly
Single Domain Antibodies - Methods and Protocols
2012The development of the hybridoma technology created the possibility to obtain unlimited amounts of monoclonal antibodies (mAb) with high specificity and affinity for any target and to introduce mAbs in a wide range of applications; however, the bulky size of mAbs, costly production, and cumbersome engineering hampered regularly their streamlined ...
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