Results 141 to 150 of about 4,782 (272)

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

A phase III study of triple therapy with budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler 320/18/9.6 μg and 160/18/9.6 μg using co-suspension delivery technology in moderate-to-very severe COPD: The ETHOS study protocol

, 2019
BACKGROUND: Single inhaler triple therapies providing an inhaled corticosteroid, a long-acting muscarinic antagonist, and a long-acting β2-agonist (ICS/LAMA/LABAs) are an emerging treatment option for chronic obstructive pulmonary disease (COPD ...
Ballal, Shaila, Darken, Patrick, Dorinsky, Paul, Ferguson, Gary T, Martinez, Fernando J, McLaren, Julie, Rabe, Klaus F, Reisner, Colin, Singh, Dave, St Rose, Earl, Trivedi, Roopa, Wang, Chen, Wedzicha, Jadwiga A   +12 more
core   +2 more sources

Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications

Small, EarlyView.
Particle shape is a key design parameter governing biological interactions. Advances in fabrication enable precise control over anisotropy and compartmentalization, allowing modulation of cellular uptake, transport, and biodistribution, ultimately enhancing therapeutic performance. ABSTRACT Polymer geometry is a primary determinant of physical behavior
Francisca G. Perfeito, Mariana B. Oliveira, João F. Mano   +2 more
wiley   +1 more source

Spartan Daily, October 2, 2003 [PDF]

, 2002
Volume 121, Issue 25https://scholarworks.sjsu.edu/spartandaily/9891/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +5 more sources

Acute Inhalation Exposure to Ultrafine Carbon Black Alters Mitochondrial Substrate Utilization in the Heart

Environmental Toxicology, EarlyView.
ABSTRACT A majority of deaths associated with air pollution are attributed to cardiovascular and heart diseases. Carbon black that represents the carbon core of particulate matter, a major component of air pollution, has been shown to result in cardiac mitochondrial dysfunction.
William E. Mullen, Jackson E. Stewart, Rahatul Islam, Salik Hussain, Dharendra Thapa   +4 more
wiley   +1 more source

Cyanogenic Compounds, Physicochemical Parameters and Metals in Water From Cassava Processing Areas: A Study in the Brazilian Amazon, Using Multivariate Analysis

Environmental Toxicology, EarlyView.
ABSTRACT This study evaluated the water quality of artesian wells and effluents generated in cassava processing in a rural area of Bragança, Pará, with emphasis on physicochemical parameters, multielement composition, and cyanogenic compounds. The well water presented specific nonconformities, highlighting pH values below the recommended level and high
Alana Coêlho Maciel, Mariane Gama Nabiça, Luciana Pinheiro Santos, Thiago de Melo e Silva, Elivaldo Nunes Modesto Junior, Heronides Adonias Dantas Filho, Charles Miller de Souza Borges, Kelly das Graças Fernandes Dantas, Simone de Fátima Pinheiro Pereira, Ivan Carlos da Costa Barbosa, Beni Jequicene Mussengue Chaúque, Rosinelson da Silva Pena, Nayara Macêdo Peixoto Araújo, Alessandra Santos Lopes   +13 more
wiley   +1 more source

Real-World Study of Single-Inhaler Triple Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol on Asthma Control in the US. [PDF]

J Asthma Allergy, 2023
Bogart M, Germain G, Laliberté F, Mahendran M, Duh MS, DiRocco K, Noorduyn SG, Paczkowski R, Balkissoon R.   +8 more
europepmc   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

Real-World Effectiveness of Single-Inhaler Triple Treatment Through Assorted Respiratory Outcomes When Switched From Multiple-Inhaler Triple Therapies (RESTART): A Prospective Cohort Study of Korean Patients With COPD

International Journal of COPD
Hana Lim,1,* Dong Han Kim,2,* Song Hee Hong,2 Juyoung Shin,1 Hyesung Lee,3 Kyeongcheol Shin,4 Seung Won Ra,5,6 Seung Jun Lee7,8 1Department of Bio Health Regulatory Science, Sungkyunkwan University, Suwon, Korea; 2Department of Social Pharmacy ...
Lim H, Kim DH, Hong SH, Shin J, Lee H, Shin K, Ra SW, Lee SJ   +7 more
doaj  

Medication adherence and persistence in chronic obstructive pulmonary disease patients receiving triple therapy in a USA commercially insured population

International Journal of COPD, 2019
Michael Bogart,1 Richard H Stanford,1 François Laliberté,2 Guillaume Germain,2 Jennifer W Wu,2 Mei Sheng Duh3 1GlaxoSmithKline plc, Research Triangle Park, NC, USA; 2Groupe d’Analyse, Ltée, Montréal, QC, Canada ...
Bogart M, Stanford RH, Laliberté F, Germain G, Wu JW, Duh MS   +5 more
doaj