Results 201 to 210 of about 7,329,727 (241)

Amyloid‐Forming Amylin Secreted by the Pancreas Promotes Hypoxia‐Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Human amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Alice E. Knapton, Nirmal Verma, Deepak Kotiya, Alice P. Sowton, Benjamin D. Thackray, Lorenz M. W. Holzner, Paula M. Darwin, Sanda Despa, Florin Despa, Andrew J. Murray   +9 more
wiley   +1 more source

Hantavirus in Dentistry: Occupational Exposure Considerations and a Proposed Tiered Infection Prevention and Control Framework—A Narrative Review

Clinical and Experimental Dental Research, Volume 12, Issue 5, October 2026.
ABSTRACT Objective The aim of this study is to synthesize evidence on hantavirus transmission and occupational exposure pathways relevant to dentistry, and to propose an evidence‐informed tiered infection prevention and control (IPC) framework that distinguishes established from theoretical risk.
Parsa Vafaei, Morteza Banakar, Mostafa Alam, Mohammad Javad Askari, Mohsen Golkar   +4 more
wiley   +1 more source

Real-life effectiveness of once-daily single-inhaler triple therapy (FF-UMEC-VI) after switching from dual therapy (ICS-LABA) in patients with symptomatic asthma: trelegy ellipta for real asthma control study. [PDF]

Front Allergy
Kushima Y, Shimizu Y, Arai R, Chibana K, Shimizu Y, Amagai M, Takemasa A, Ikeda N, Masawa M, Kushima A, Okutomi H, Nakamura Y, Tei R, Ando Y, Yazawa N, Goto Y, Haruyama Y, Yukawa T, Niho S.   +18 more
europepmc   +1 more source

Mechanism of ORC1 Regulating Cancer Stemness and Cisplatin Resistance in Non‐Small Cell Lung Cancer

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Elevated ORC1 expression in non‐small cell lung cancer (NSCLC) simultaneously activates cancer stemness and epithelial‐mesenchymal transition (EMT). Upregulation of stemness‐associated factors (NANOG, LGR5, CD133+CD44+ CSCs) and EMT transcription factors (SNAI1, SNAI2, TWIST1) synergistically induce MDR1 overexpression. Increased MDR1 ultimately drives
Jianhui Sheng, Yingjian Song
wiley   +1 more source

Real-World Effectiveness of Fluticasone Furoate/Umeclidinium/Vilanterol Once-Daily Single-Inhaler Triple Therapy for Symptomatic COPD: The ELLITHE Non-Interventional Trial. [PDF]

Int J Chron Obstruct Pulmon Dis
Beeh KM, Scheithe K, Schmutzler H, Krüger S.   +3 more
europepmc   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Outcomes of patients with COPD switching from multiple-inhaler to once-daily single-inhaler triple therapy in a real-world primary care setting in England: a retrospective pre-post cohort study. [PDF]

BMJ Open Respir Res
Rothnie KJ, Wood RP, Czira A, Banks VL, Camidge LJ, Massey OKI, Seif M, Compton C, Sharma R, Halpin DMG, Ismaila AS, Vogelmeier CF.   +11 more
europepmc   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Outcomes of Patients with COPD Treated with ICS/LABA Before and After Initiation of Single-Inhaler Triple Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI). [PDF]

Adv Ther
McCormack M, Paczkowski R, Gronroos NN, Noorduyn SG, Lee L, Veeranki P, Johnson MG, Igboekwe E, Kahle-Wrobleski K, Panettieri R.   +9 more
europepmc   +1 more source

Variant Class–Specific Phenotypes and Outcomes in Pediatric TBX4‐Associated Pulmonary Hypertension

Pediatric Pulmonology, Volume 61, Issue 10, October 2026.
ABSTRACT Aim To describe the variant class associations with phenotype, natural history, treatment response, and outcomes in children with TBX4‐associated pulmonary hypertension (TBX4‐PH). Methods Retrospective cohort analysis of children < 18 years referred to the National Paediatric Pulmonary Hypertension Service between 2001 and 2025. Results Twenty‐
Cara Morgan, Alistair Calder, Matina Prapa, Thivya Sekar, Andrew Constantine, Tomas Woodgate, Annabelle Barnes, Eimear McGovern, Paul Aurora, Rossa Brugha, Sadia Quyam, Andrew Bush, Shahin Moledina   +12 more
wiley   +1 more source