Results 211 to 220 of about 4,782 (272)

Single Triple vs Dual Inhaler Therapy [PDF]

, 2019
Brian J. Lipworth, Calzetta, Chris R.W. Kuo, Ferguson, Lipson, Short, Singh   +6 more
core   +2 more sources

Effect of Anthocyanin‐Rich New Zealand Blackcurrant on Tumour Necrosis Factor‐α–Induced Plasminogen Activator Inhibitor‐1 Release in Airway Epithelial Cells: A Preliminary Study

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
Pretreatment with New Zealand blackcurrant anthocyanins nonsignificantly reduced TNF‐α–induced PAI‐1 release in bronchial epithelial cells. The small sample size may have influenced the lack of statistical significance. This study provides preliminary evidence of possible effects of NZBC anthocyanins on PAI‐1 secretion but warrants further extensive ...
Madiha Ajaz, Ayesha Zahid, Rati Jani, Lada Vugic, Indu Singh, Natalie Shilton   +5 more
wiley   +1 more source

Adherence and Persistence with Single-Inhaler Triple Therapy Among Patients with COPD Using Commercial and Medicare Advantage US Health Plan Claims Data. [PDF]

Adv Ther
Young C, Lee LY, DiRocco KK, Germain G, Klimek J, Laliberté F, Lejeune D, Noorduyn SG, Paczkowski R.   +8 more
europepmc   +1 more source

Prevalence and Burden of Dyspnoea Among Patients with Chronic Obstructive Pulmonary Disease in Five European Countries [PDF]

, 2016
Hana Mullerova, Ian Naya, Manuel Valle, Mark Small, Robert Wood, Tim Holbrook, Yogesh Suresh Punekar   +6 more
core   +1 more source

Optimizing Venous Thromboembolism Prophylaxis in Burn Patients Using Enoxaparin Through PBPK Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 6, June 2026.
ABSTRACT Burn injuries cause physiological changes that alter enoxaparin pharmacokinetics, often leading to inadequate exposure and suboptimal venous thromboembolism (VTE) prophylaxis. Current weight‐based dosing and anti‐Xa monitoring provide limited guidance for dose optimization across burn severities.
Sabiha Rahman Mim, Venkata K. Yellepeddi, Francine J. Azeredo   +2 more
wiley   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, Volume 183, Issue 11, Page 2660-2674, June 2026.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

British Journal of Pharmacology, Volume 183, Issue 11, Page 2675-2694, June 2026.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng, Yuanjun Tang, Xuedi Cao, Xiaotong Yu, Zhanya Huang, Yunyun Guo, Renjing Jin, Yan Wang, Yang Liu, Lixiang Xue, Yuqing Wang   +10 more
wiley   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, Volume 183, Issue 11, Page 2947-2968, June 2026.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Real-life effectiveness of once-daily single-inhaler triple therapy (FF-UMEC-VI) after switching from dual therapy (ICS-LABA) in patients with symptomatic asthma: trelegy ellipta for real asthma control study. [PDF]

Front Allergy
Kushima Y, Shimizu Y, Arai R, Chibana K, Shimizu Y, Amagai M, Takemasa A, Ikeda N, Masawa M, Kushima A, Okutomi H, Nakamura Y, Tei R, Ando Y, Yazawa N, Goto Y, Haruyama Y, Yukawa T, Niho S.   +18 more
europepmc   +1 more source

Impact of Electronic Cigarette Use on the Oral Microbiota: A Systematic Review

Journal of Clinical Periodontology, Volume 53, Issue 6, Page 956-985, June 2026.
ABSTRACT Aim To examine whether the oral microbiota of e‐cigarette users differs from that of never smokers and current smokers. Materials and Methods PubMed, Scopus and Web of Science were searched on 27 August 2025. Human studies using molecular methods to compare oral microbiota in saliva, subgingival plaque and oral mucosal swabs among e‐cigarette ...
Giusy Rita Maria La Rosa, Lakshman Perera Samaranayake, Egija Zaura, Ang Sun, Virginia Fuochi, Pio Maria Furneri, Jan Kowalski, Karol Myszel, Iain Chapple, Riccardo Polosa   +9 more
wiley   +1 more source