Results 61 to 70 of about 146,554 (263)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Wavelength switchable and stable single-longitudinal-mode erbium-doped fiber laser based on Mach–Zehnder interferometer and tunable filter

International Journal of Optomechatronics, 2018
An erbium-doped fiber laser with all-fiber Mach–Zehnder interferometer (MZI) and tunable filter was proposed and experimentally demonstrated. In the designed fiber laser, 6 m C-band erbium-doped fiber was selected as a gain medium; the MZI comprised two ...
Wei He, Lianqing Zhu, Mingli Dong, Fei Luo   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Hybrid dual-wavelength pumped gain-switched single-frequency pulsed Tm3+-doped fiber laser at 2.1 μm

Applied Physics Express
An efficient gain-switched single-frequency Tm ^3+ -doped fiber laser at 2097.48 nm using a short DBR cavity under hybrid pumping (1570 nm pulsed and 793 nm continuous wave) is experimentally demonstrated.
Kaixuan Wu, Guowu Tang, Weichao Wang, Jialong Li, Qilai Zhao, Changsheng Yang   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Broad Continuous Temperature Tunable DBR Single-Frequency Fiber Laser at 1064 nm

IEEE Photonics Journal, 2016
Based on a temperature-dependent longitudinal-mode-selection model, a broad temperature range for single-longitudinal-mode (SLM) operation of a short DBR phosphate fiber laser has been demonstrated.
Yuning Zhang, Can Li, Shanhui Xu, Huaqiu Deng, Zhouming Feng, Changsheng Yang, Xiang Huang, Yuanfei Zhang, Jiulin Gan, Zhongmin Yang   +9 more
doaj   +1 more source

How to control the laser emission in single longitudinal mode

Optica Pura y Aplicada, 2015
Producción ...
González Fernández, Verónica, Vasallo, E., Pérez Callejo, Gabriel, Grützmacher, K., Fuentes García, Luis María, Pérez, C., Rosa García, María Inmaculada de la   +6 more
openaire   +1 more source