Results 61 to 70 of about 7,974,684 (288)

Single-longitudinal-mode vortex Nd:YVO4 laser using a circular Dammann grating for pump shaping

Applied Physics Express
In this research, a 1064 nm single-longitudinal-mode (SLM) vortex beam was generated from an annular-pumped Nd:YVO _4 microchip laser, in which a circular Dammann grating was used to reshape the 808 nm pump light into an annular intensity profile.
Jiaxin Song, Junjie Yu, Weilin Cao, Yuefei Li, Dawei Zhang, Jianlang Li   +5 more
doaj   +1 more source

Longitudinal mode-coupling instabilities of proton bunches in the CERN Super Proton Synchrotron

Physical Review Accelerators and Beams, 2023
In this paper, we study single-bunch instabilities observed in the CERN Super Proton Synchrotron (SPS). According to the linearized Vlasov theory, radial or azimuthal mode-coupling instabilities result from a coupling of bunch-oscillation modes, which ...
Ivan Karpov
doaj   +1 more source

Wavelength-Switchable Single-Longitudinal- Mode Thulium-Doped Fiber Laser With Sampled Fiber Bragg Grating

IEEE Access, 2021
A wavelength-switchable single-longitudinal-mode thulium-doped fiber laser using a sampled fiber Bragg grating is proposed in this study. The laser can be switched between three single-wavelength and three dual-wavelength modes of operation.
Wenguo Han, Fengping Yan, Ting Feng, Luna Zhang, Biao Guan, Qi Qin, Ying Guo, Ting Li, Hong Zhou, Yuping Suo   +9 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nonlinear longitudinal/transversal modal interactions in highly extensible suspended cables [PDF]

, 2008
Recent research literature mostly deals with nonlinear resonant dynamics of low-extensible cables involving transversal modes. Herein, we aim to investigate geometrically nonlinear longitudinal/transversal modal interactions in highly extensible ...
Rega, G., Srinil, N.
core   +4 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Non-astigmatic Alexandrite ring laser design with wavelength-tunable single-longitudinal-mode operation [PDF]

, 2020
This work presents a study of a fully nonastigmatic design of a single-longitudinal-mode, wavelength-tunable, unidirectional alexandrite ring laser cavity and assessment of its performance compared to more complex laser design requiring astigmatism ...
Sheng, xin, Minassian, ara, Damzen, Michael, Sathian, juna, Tawy, goronwy   +4 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source