Results 11 to 20 of about 1,085,849 (268)
Single-molecule FRET uncovers hidden conformations and dynamics of human Argonaute 2
Nature Communications, 2022 Single-molecule FRET measurements provide detailed insights into the conformational states and dynamics of human Argonaute 2 that are required for its function at the core of the eukaryotic RNA silencing pathway.
Sarah Willkomm +6 more
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BMC Biology, 2018 Background Higher-order self-assembly of proteins, or “prion-like” polymerisation, is now emerging as a simple and robust mechanism for signal amplification, in particular within the innate immune system, where the recognition of pathogens or danger ...
Ailís O’Carroll +11 more
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Spontaneous Confinement of mRNA Molecules at Biomolecular Condensate Boundaries
Cells, 2023 Cellular biomolecular condensates, termed ribonucleoprotein (RNP) granules, are often enriched in messenger RNA (mRNA) molecules relative to the surrounding cytoplasm.
Rebecca T. Perelman +3 more
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Single Molecule Nanometronome [PDF]
Nano Letters, 2006 We constructed a DNA-based nanomechanical device called the nanometronome. Our device is made by introducing complementary single-stranded overhangs at the two arms of the DNA four-way junction. The ticking rates of this stochastic metronome depend on ion concentrations and can be changed by a set of DNA-based switches to deactivate/reactivate the ...
Chittanon, Buranachai +2 more
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Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin
Nature Communications, 2023 Force transmission at integrin-based adhesions is important for cell migration and mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to integrins.
Sawako Yamashiro +5 more
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Direct-laser writing for subnanometer focusing and single-molecule imaging
Nature Communications, 2022 Focus-locking improves localization precision in single-molecule microscopy, but fiducials are often deposited at random and provide limited 3D compensation.
Simao Coelho +4 more
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eLife, 2022 Single molecule imaging has shown that part of actin disassembles within a few seconds after incorporation into the dendritic filament network in lamellipodia, suggestive of frequent destabilization near barbed ends.
Danielle Holz +5 more
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Nature Communications, 2016 In response to intracellular signals, bacterial translational riboswitches embedded in mRNAs can regulate gene expression through inhibition of translation initiation.
Arlie J. Rinaldi +3 more
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Verification of Single-Molecule Imaging and Single-Molecule Measurements
Journal of Robotics and Mechatronics, 2010 Single-molecule imaging and single-molecule measurements constitute an integral part of life science researches. The research method, which allows direct measurements of individual motions and events of biomolecules, has contributed much to the development of life science research by providing us with numerous findings. It is left up to the judgment of
Akihiko Ishijima +2 more
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Single‐molecule genomics [PDF]
The Journal of Pathology, 2009 AbstractThe term ‘single‐molecule genomics’ (SMG) describes a group of molecular methods in which single molecules are detected or sequenced. The focus on the analysis of individual molecules distinguishes these techniques from more traditional methods, in which template DNA is cloned or PCR‐amplified prior to analysis. Although technically challenging,
Frank, McCaughan, Paul H, Dear
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