Results 21 to 30 of about 1,085,849 (268)
An intermolecular FRET sensor detects the dynamics of T cell receptor clustering
Nature Communications, 2017 Cellular signalling is often facilitated by membrane protein clustering, but detection of protein clustering at high spatiotemporal resolution is challenging.
Yuanqing Ma +8 more
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Resolving Subcellular miRNA Trafficking and Turnover at Single-Molecule Resolution
Cell Reports, 2017 Summary: Regulation of microRNA (miRNA) localization and stability is critical for their extensive cytoplasmic RNA silencing activity and emerging nuclear functions.
Sethuramasundaram Pitchiaya +4 more
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iScience, 2021 Summary: Single-molecule localization microscopy (SMLM) reports on protein organization in cells with near-molecular resolution and in combination with stoichiometric labeling enables protein counting.
Tim N. Baldering +8 more
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Pulling on single molecules [PDF]
Nature Methods, 2012 Single-molecule methods to apply and measure force and displacement are expanding mechanobiology.
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Single-molecule detection on a portable 3D-printed microscope
Nature Communications, 2019 Single-molecule in vitro assays require dedicated confocal microscopes equipped with fluorescence correlation spectroscopy (FCS) modules. Here the authors present a compact, cheap and open-source 3D-printed confocal microscope for single photon counting ...
James W. P. Brown +7 more
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STAR Protocols, 2023 Summary: Multiplexed high-density label super-resolution microscopy image reconstruction by integrating exchangeable single-molecule localization (IRIS) enables elucidating fine structures and molecular distribution in cells and tissues.
Qianli Zhang +2 more
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Frontiers in Molecular Biosciences, 2021 In addition to the canonical double helix form, DNA is known to be extrapolated into several other secondary structural patterns involving themselves in inter- and intramolecular type hydrogen bonding. The secondary structures of nucleic acids go through
Debolina Bandyopadhyay +3 more
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Single-Molecule Reaction-Diffusion
Biophysical Journal, 2023 Abstract We propose to capture reaction-diffusion on a molecule-by-molecule basis from the fastest acquirable timescale, namely individual photon arrivals. We illustrate our method on intrinsically disordered human proteins, the linker histone H1.0 as well as its chaperone prothymosin α
Lance W.Q. Xu +3 more
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Proceedings of the National Academy of Sciences, 2005 We have designed and synthesized a molecular rod that consists of two weakly coupled electronic π -systems with mutually shifted energy levels. The asymmetry thus implied manifests itself in a current–voltage characteristic with pronounced dependence on the sign of the bias voltage, which makes the molecule a prototype for a molecular diode.
Elbing, M. +9 more
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Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis
Cell Structure and Function, 2023 In eukaryotic motile cells, the active Ras (Ras-GTP)-enriched domain is generated in an asymmetric manner on the cell membrane through the excitable dynamics of an intracellular signaling network.
Da Young Shin +4 more
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