Results 261 to 270 of about 6,253,377 (301)

An ATP-Driven N Protein-DDX21 Molecular Switch Dynamically Controls SARS-CoV-2 RNA G-Quadruplex Heterogeneity. [PDF]

Adv Sci (Weinh)
Zheng YT, Zhai LY, Jin J, Chen QY, Fu H, Sun XQ, Lu Y, Li H, Hou XM.   +8 more
europepmc   +1 more source

Single-Molecule AFM-Based Force Spectroscopy Reveals VLA-4/VCAM-1 Interactions Underlying Chemokine-Independent B16 Melanoma Cell Arrest. [PDF]

Biology (Basel)
Eibl RH.
europepmc   +1 more source

ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter. [PDF]

Elife
Pečak M, Nocker C, Tampé R.
europepmc   +1 more source

Semantic knowledge improves molecular machine learning for chemical toxicity prediction. [PDF]

iScience
Albi G, Dagliati A, Bellazzi R, Romano JD.   +3 more
europepmc   +1 more source

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Enzyme Assays for Confocal Single Molecule Spectroscopy

Current Pharmaceutical Biotechnology, 2004
During the last years confocal techniques have become increasingly popular for probing biological enzymatic reactions. In this paper we will summarize some of these methods, mainly focusing on measurement techniques suitable for analysis of freely diffusing molecules, where either the substrates or the enzymes are fluorescently labeled.
Jahnz, M., Schwille, P.
openaire   +3 more sources

Statistical Analysis of Single-Molecule Colocalization Assays

Analytical Chemistry, 2001
In chemical assays, specific molecular recognition events result in close physical proximity of two molecular species, e.g., ligands and receptors. Microscopy techniques that are able to image individual molecules allow for achieving a positional accuracy far beyond the resolution limit Therefore, independent position determination, e.g., by dual-color
Trabesinger W, Hecht B, Wild UP, Schütz GJ, Schindler H, Schmidt T   +5 more
openaire   +3 more sources

Advances in Optical Single‐Molecule Detection: En Route to Supersensitive Bioaffinity Assays

Angewandte Chemie - International Edition, 2020
The ability to detect low concentrations of analytes and in particular low-abundance biomarkers is of fundamental importance, e.g., for early-stage disease diagnosis.
Matthias Mickert, Matej Pastucha, Petr Skládal   +2 more
exaly   +2 more sources

Single-molecule assays for investigating protein misfolding and aggregation

Physical Chemistry Chemical Physics, 2013
Protein misfolding and aggregation are relevant to many fields. Recently, their investigation has experienced a revival as a central topic in the research of numerous human diseases, including Parkinson's and Alzheimer's. Much has been learned from ensemble biochemical approaches, but the inherently heterogeneous nature of the underlying processes has ...
Hoffmann, Armin, Neupane, Krishna, Woodside, Michael T.   +2 more
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Single-molecule assay of ubiquitylation

Science Signaling, 2015
The basis of an important enzyme-target recognition strategy is revealed at the single-molecule level.
openaire   +1 more source

Single-Molecule FRET Assay for Studying Cotranscriptional RNA Folding

2019
Cotranscriptional RNA folding plays important roles in gene regulation steps such as splicing, transcription termination, and translation initiation. Progression of our understanding of cotranscriptional RNA folding mechanisms is still retarded by the lacking of experimental tools to study the kinetics of cotranscriptional RNA folding properly. In this
Heesoo, Uhm, Sungchul, Hohng
openaire   +2 more sources