Results 251 to 260 of about 737,082 (371)

Single Nucleotide Polymorphisms in Proximity to K‐Channel Genes Are Associated with Decreased Longitudinal QTc Variance [PDF]

, 2013
Yuliya Mints, Vadim Zipunnikov, Irfan Khurram, Hugh Calkins, Saman Nazarian   +4 more
openalex   +1 more source

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

The Genetic Structure and Diversity of Different Pigeon Breeds Based on a 5 K Single Nucleotide Polymorphism Chip. [PDF]

Animals (Basel)
Hou H, Li X, Wang X, Cai X, Tu Y, Lv W, Shen X, Yang C, Yao J.   +8 more
europepmc   +1 more source

Genomic copy number of a carcinogenic single nucleotide polymorphism at 8q24 in non‐risk allele colorectal cancer associated with insulin growth factor 2 receptor expression [PDF]

, 2012
Yusuke Takahashi, Koshi Mimori, Ken Yamamoto, Masahiko Watanabe, Junichi Tanaka, Shin‐ei Kudo, K. Sugihara, Kazuo Hase, Hidetaka Mochizuki, Masato Kusunoki, Kazutaka Yamada, Yasuhiro Shimada, Yoshihiro Moriya, Masaki Mori   +13 more
openalex   +1 more source

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Does the Single Nucleotide Polymorphism rs2228145 in IL6R Truly Reflect IL-6 Signaling in Mendelian Randomization Studies? [PDF]

Immune Netw
Zhu M, Cao M, Lin L.
europepmc   +1 more source

Chromosome 1 and parameters associated with the quantitative trait loci (QTL) for seed N, P, and S in ‘Forrest’ by ‘Williams 82’ recombinant inbred soybean lines (RILs) population. A total of 5405 single nucleotides polymorphism (SNP) markers using Infinium NP6K BeadChips. A total 2075 polymorphic SNPs were mapped on the 20 soybean chromosomes.

Nacer Bellaloui (752956), Jiazheng Yuan (9724193), Dounya Knizia (21600272), Qijian Song (277210), Frances Betts (22177311), Teresa Register (22177314), Earl Williams (22177317), Naoufal Lakhssassi (841280), Hamid Mazouz (22177320), Henry T. Nguyen (8468994), Khalid Meksem (43356), Alemu Mengistu (752959), My Abdelmajid Kassem (21600284)   +12 more
openalex   +1 more source

Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study [PDF]

, 2016
Sofus C. Larsen, Lars Ängquist, Jane Nautrup Østergaard, Tarunveer S. Ahluwalia, Karani S. Vimaleswaran, Nina Roswall, Lotte Maxild Mortensen, B. Nielsen, Anne Tjønneland, Nicholas J. Wareham, Domenico Palli, Giovanna Masala, Wim H. M. Saris, Daphne L. van der A, Jolanda M.A. Boer, Edith J. M. Feskens, Heiner Boeing, Marianne Uhre Jakobsen, Ruth J. F. Loos, Thorkild I. A. Sørensen, Kim Overvad   +20 more
openalex   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Clinical study of single nucleotide polymorphism-based chromosome microarray analysis in the etiological diagnosis of fetal congenital heart disease. [PDF]

Sci Rep
Zheng Y, Xue S, Ding G, Zhang L, Ding G.
europepmc   +1 more source