Results 251 to 260 of about 730,667 (367)

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic   +4 more
wiley   +1 more source

Peer Review #1 of "Obesity in the Balinese is associated with FTO rs9939609 and rs1421085 single nucleotide polymorphisms (v0.1)"

open access: gold, 2020
Lidwina Priliani   +9 more
openalex   +1 more source

Biology and therapeutic implications of VEGF-A splice isoforms and single-nucleotide polymorphisms in colorectal cancer [PDF]

open access: bronze, 2016
Miriam Canavese   +5 more
openalex   +1 more source

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1998
Cherie E. Bond   +12 more
semanticscholar   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe   +6 more
wiley   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

open access: yesBarrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Multi‐omics profiling identified two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics

open access: yes
Cancer Communications, EarlyView.
Carine Ngo   +30 more
wiley   +1 more source

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