Results 91 to 100 of about 261,642 (181)

Genomic signatures of heterokaryosis in the oomycete pathogen Bremia lactucae. [PDF]

, 2019
Lettuce downy mildew caused by Bremia lactucae is the most important disease of lettuce globally. This oomycete is highly variable and rapidly overcomes resistance genes and fungicides.
Bertier, Lien D, Cavanaugh, Keri, Fletcher, Kyle, Gil, Juliana, Kenefick, Aubrey, Michelmore, Richard, Reyes-Chin-Wo, Sebastian, Tsuchida, Cayla, Wong, Joan, Wood, Kelsey J, Zhang, Lin   +10 more
core  

Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors

Nature Communications
Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are rare, aggressive mesenchymal neoplasms with high recurrence and metastasis rates.
Chenhui Zhao, Xueyan Hu, Xiudong Guan, Xiaojun Fu, Tingting Wang, Mengyuan Li, Xinze Liu, Jiarui Zhao, Di Wu, Fan Zhang, Jiaying Fu, Jiang Li, Tieqiang Zhang, Xiaochun Jiang, Changxiang Yan, Wang Jia, Ence Yang, Jian Chen   +17 more
doaj   +1 more source

The interplay between viral-derived miRNAs and host immunity during infection [PDF]

, 2019
MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection.
Ingle, Harshad, Kumar, Ashish, Kumar, Himanshu, Mishra, Richa   +3 more
core   +1 more source

Integration of single-nucleus and exosome RNA sequencing dissected inter-cellular communication and biomarkers in pancreatic ductal adenocarcinoma

Computational and Structural Biotechnology Journal
Background: Mounting evidence underscores the importance of cell communication within the tumor microenvironment, which is pivotal in tumor proliferation, invasion, and metastasis. Exosomes play a crucial role in cell-to-cell communication.
Rong Tang, Zifeng Zhang, Jin Xu, Wei Wang, Qingcai Meng, Yuan Liu, Qiong Du, Chen Liang, Jie Hua, Bo Zhang, Xianjun Yu, Si Shi   +11 more
doaj   +1 more source

Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression. [PDF]

, 2016
BackgroundAstronauts are exposed to 56Fe ions that may pose a significant health hazard during and following prolonged missions in deep space. We showed previously that object recognition requiring the hippocampus, a structure critical for cognitive ...
Fareh, Fatema, Impey, Soren, Jopson, Timothy, Marzulla, Tessa, Pelz, Carl, Raber, Jacob, Riparip, Lara-Kirstie, Rosi, Susanna, Stewart, Blair, Tafessu, Amanuel, Turker, Mitchell S, Zuloaga, Damian   +11 more
core  

Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. [PDF]

, 1993
A polymerase chain reaction strategy was devised to identify new members of the mammalian myosin I family of actin-based motors. Using cellular RNA from mouse granular neurons and PC12 cells, we have cloned and sequenced three 1.2-kb polymerase chain ...
Greene, LA, Joyce, MP, Sherr, EH
core  

Advances in Single-Cell Sequencing for Understanding and Treating Kidney Disease

Computation
The fields of medical diagnostics, nephrology, and the sequencing of cellular genetic material are pivotal for precise quantification of kidney diseases.
Jose L. Agraz, Amit Verma, Claudia M. Agraz   +2 more
doaj   +1 more source

Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia

AbstractVascular dementia (VaD) refers to a variety of dementias driven by cerebrovascular disease and is the second leading cause of dementia globally. VaD may be caused by ischemic strokes, intracerebral hemorrhage, and/or cerebral small vessel disease, commonly identified as white matter hyperintensities on MRI. The mechanisms underlying these white
Sebastián Díaz-Pérez, Jonathan H. DeLong, Cyprien A. Rivier, Chia-Yi Lee, Michael H. Askenase, Biqing Zhu, Le Zhang, Kristen J. Brennand, Andrew J. Martins, Lauren H. Sansing   +9 more
openaire   +2 more sources

Missing cell types in single-cell references impact deconvolution of bulk data but are detectable

Genome Biology
Background Advancements in RNA sequencing have expanded our ability to study gene expression profiles of biological samples in bulk tissue and single cells.
Adriana Ivich, Natalie R. Davidson, Laurie Grieshober, Weishan Li, Stephanie C. Hicks, Jennifer A. Doherty, Casey S. Greene   +6 more
doaj   +1 more source

A single-cell transcriptomic atlas of all cell types in the brain of 5xFAD Alzheimer mice in response to dietary inulin supplementation

BMC Biology
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is a major threat to the aging population. Due to lack of effective therapy, preventive treatments are important strategies to limit AD onset and progression, of which ...
Xiaoyan Wang, Houyu Zhang, Zhou Wan, Xuetong Li, Carlos F. Ibáñez, Meng Xie   +5 more
doaj   +1 more source