Results 71 to 80 of about 261,642 (181)

snRNA-seq of long-preserved FFPE samples from colorectal liver metastasis lesions with diverse prognoses

Scientific Data
Differences in prognostic outcomes are prevalent in patients with colorectal cancer liver metastases. Comparative analysis of tissue samples, particularly applying single-cell transcriptome sequencing technology, can provide a deeper understanding of ...
Hongyu Chen, Xiang Zhang, Qing Cheng, Xiner Shen, Linghui Zeng, Yongcheng Wang, Longjiang Fan, Weiqin Jiang   +7 more
doaj   +1 more source

The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43

, 2019
The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored.
Bansal, V., Bonn, S., Fornasiero, E., Fritsch, E., Gomes, L., Gärtner, A., Keihani, S., Klüver, V., Kügler, S., Mandad, S., Rahman, R., Rizzoli, S., Urlaub, H., Wren, J.   +13 more
core   +1 more source

Oyster RNA-seq data support the development of Malacoherpesviridae genomics [PDF]

, 2017
The family of double-stranded DNA (dsDNA) Malacoherpesviridae includes viruses able to infect marine mollusks and detrimental for worldwide aquaculture production. Due to fast-occurring mortality and a lack of permissive cell lines, the available data on
Rosani, Umberto, Venier, Paola
core   +2 more sources

Single-nucleus RNA (snRNA) sequencing v1

Step-by-step protocol describing the snRNA sequencing workflow for nuclei isolated from post-mortem human brain tissue.
Anita Adami, Raquel Garza
openaire   +1 more source

Metaxa : a software tool for automated detection and discrimination among ribosomal small subunit (12S/16S/18S) sequences of archaea, bacteria, eukaryotes, mitochondria, and chloroplasts in metagenomes and environmental sequencing datasets [PDF]

, 2011
Peer ...
Abarenkov, Kessy, Bengtsson, Johan, Eriksson, K. Martin, Grelet, Gwen-Aelle, Hartmann, Martin, Nilsson, R. Henrik, Petri, Anna, Rosenblad, Magnus Alm, Shenoy, Belle Damodara, Wang, Zheng   +9 more
core   +1 more source

Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing [PDF]

Nature Neuroscience, 2018
In females with X-linked genetic disorders, wild-type and mutant cells coexist within brain tissue because of X-chromosome inactivation, posing challenges for interpreting the effects of X-linked mutant alleles on gene expression. We present a single-nucleus RNA sequencing approach that resolves mosaicism by using single-nucleotide polymorphisms in ...
William Renthal, Lisa D. Boxer, Sinisa Hrvatin, Emmy Li, Andrew Silberfeld, M. Aurel Nagy, Eric C. Griffith, Thomas Vierbuchen, Michael E. Greenberg   +8 more
openaire   +2 more sources

Comprehensive sequencing of the lung neuroimmune landscape in response to asthmatic induction

Frontiers in Immunology
IntroductionEvidence demonstrates that sensory neurons respond to pathogenic/allergic infiltration and mediate immune responses, forming an integral part of host defense that becomes hypersensitized during allergy.
Hayden McSwiggin, Rui Wang, Rubens Daniel Miserani Magalhães, Fengli Zhu, Taylor A. Doherty, Wei Yan, Wei Yan, Nicholas Jendzjowsky, Nicholas Jendzjowsky   +8 more
doaj   +1 more source

Single cell atlas for 11 non-model mammals, reptiles and birds

Nature Communications, 2021
Here the authors report single-nucleus RNA sequencing for several anatomical locations in 11 species, including cat, dog, hamster, lizard, goat, rabbit, duck, pigeon, pangolin, tiger, and deer, highlighting coexpression of SARS-CoV-2 entry factors ACE2 ...
Dongsheng Chen, Jian Sun, Jiacheng Zhu, Xiangning Ding, Tianming Lan, Xiran Wang, Weiying Wu, Zhihua Ou, Linnan Zhu, Peiwen Ding, Haoyu Wang, Lihua Luo, Rong Xiang, Xiaoling Wang, Jiaying Qiu, Shiyou Wang, Haimeng Li, Chaochao Chai, Langchao Liang, Fuyu An, Le Zhang, Lei Han, Yixin Zhu, Feiyue Wang, Yuting Yuan, Wendi Wu, Chengcheng Sun, Haorong Lu, Jihong Wu, Xinghuai Sun, Shenghai Zhang, Sunil Kumar Sahu, Ping Liu, Jun Xia, Lijing Zhang, Haixia Chen, Dongming Fang, Yuying Zeng, Yiquan Wu, Zehua Cui, Qian He, Sanjie Jiang, Xiaoyan Ma, Weimin Feng, Yan Xu, Fang Li, Zhongmin Liu, Lei Chen, Fang Chen, Xin Jin, Wei Qiu, Tianjiao Wang, Yang Li, Xiumei Xing, Huanming Yang, Yanchun Xu, Yan Hua, Yahong Liu, Huan Liu, Xun Xu   +59 more
doaj   +1 more source

FLASH: ultra-fast protocol to identify RNA-protein interactions in cells

, 2019
Determination of the in vivo binding sites of RNA-binding proteins (RBPs) is paramount to understanding their function and how they affect different aspects of gene regulation.
Akhtar, A., Aktas, T., Backofen, R., Ilik, I., Maticzka, D.   +4 more
core   +1 more source

The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]

, 2018
The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S, Klimstra, William B, Lucas, Tiffany M, Ryman, Kate D, Sun, Chengqun, Trobaugh, Derek W, Weiss, Christopher M   +6 more
core   +2 more sources