Results 81 to 90 of about 261,642 (181)

PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis

Signal Transduction and Targeted Therapy
Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks have not been systematically described because of the limitations in detecting ...
Liang Chen, Haotong Li, Xiaorui Liu, Ningning Zhang, Kui Wang, Anteng Shi, Hang Gao, Deniz Akdis, Ardan M. Saguner, Xinjie Xu, Elena Osto, Willem Van de Veen, Guangyu Li, Antoni Bayés-Genís, Firat Duru, Jiangping Song, Xiangjie Li, Shengshou Hu   +17 more
doaj   +1 more source

lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression

BMC Genomics
Background Relative cell type fraction estimates in bulk RNA-sequencing data are important to control for cell composition differences across heterogenous tissue samples.
Sean K. Maden, Louise A. Huuki-Myers, Sang Ho Kwon, Leonardo Collado-Torres, Kristen R. Maynard, Stephanie C. Hicks   +5 more
doaj   +1 more source

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source

Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. [PDF]

, 2019
Genome wide association studies (GWAS) in obesity have identified a large number of noncoding loci located near genes expressed in the central nervous system.
Ahituv, Nadav, Eckalbar, Walter L, Inoue, Fumitaka, Matharu, Navneet, Murphy, Karl K, Vaisse, Christian, Wang, Yi   +6 more
core   +1 more source

Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The Fontan operation is the current standard of care for single‐ventricle congenital heart disease. Almost all patients with Fontan operation develop liver fibrosis at a young age, known as Fontan‐associated liver disease (FALD).
Rasheed Sule, Po Hu, Clarissa Shoffler, Christopher Petucci, Benjamin J. Wilkins, Jack Rychik, Liming Pei   +6 more
doaj   +1 more source

Single-cell and spatial omics: exploring hypothalamic heterogeneity

Neural Regeneration Research
Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions.
Muhammad Junaid, Eun Jeong Lee, Su Bin Lim   +2 more
doaj   +1 more source

Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships

AbstractAs relationships mature, partners share common goals, improve their ability to work together, and experience coordinated emotions. However, the neural underpinnings responsible for this unique, pair-specific experience remain largely unexplored.
Liza E. Brusman, Julie M. Sadino, Allison C. Fultz, Michael A. Kelberman, Robin D. Dowell, Mary A. Allen, Zoe R. Donaldson   +6 more
openaire   +2 more sources

Optimized Method for High-Quality Isolation of Single-Nuclei From Mosquito Fat Body for RNA Sequencing

Bio-Protocol
Single-cell and single-nucleus RNA sequencing are revolutionizing our understanding of cellular biology. The identification of molecular markers, single-cell transcriptomic profiling, and differential gene expression at the cellular level has revealed ...
Stephanie de Carvalho, Colton McNinch, Carolina Barillas-Mury   +2 more
doaj   +1 more source

Twisted Tales: Insights into Genome Diversity of Ciliates Using Single-Cell 'Omics. [PDF]

, 2018
The emergence of robust single-cell 'omics techniques enables studies of uncultivable species, allowing for the (re)discovery of diverse genomic features.
Katz, Laura A, Knight, Rob, Maurer-Alcalá, Xyrus X, Pilling, Olivia A, Yan, Ying   +4 more
core   +1 more source

Transposable Elements, Inflammation, and Neurological Disease. [PDF]

, 2019
Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela, Muotri, Alysson R, Saleh, Aurian   +2 more
core