Results 81 to 90 of about 173,386 (236)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

High-throughput in situ single particle X-ray imaging of dehydrating viral capsids

Light: Science & Applications
Single-stranded RNA viruses co-assemble their capsid with the genome, and variations in capsid structures can have significant functional relevance. In particular, viruses need to respond to a dehydrating environment to prevent genomic degradation and ...
Abhishek Mall, Anna Munke, Parichita Mazumder, Zhou Shen, Johan Bielecki, Juncheng E, Armando D. Estillore, Chan Kim, Romain Letrun, Jannik Lübke, Safi Rafie-Zinedine, Adam Round, Ekaterina Round, Michael Rütten, Amit K. Samanta, Abhisakh Sarma, Tokushi Sato, Florian Schulz, Carolin Seuring, Tamme Wollweber, Lena Worbs, Patrik Vagovic, Richard Bean, Adrian P. Mancuso, Ne-Te Duane Loh, Tobias Beck, Jochen Küpper, Filipe R.N.C. Maia, Henry N. Chapman, Kartik Ayyer   +29 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

An ultrafast plenoptic-camera system for high-resolution 3D particle tracking in unsegmented scintillators

Nature Communications
Neutrino detectors, particle calorimeters and some dark matter detectors require dense and massive active materials. An extremely fine segmentation is desirable to achieve precise three-dimensional particle tracking.
Till Dieminger, Saúl Alonso-Monsalve, Christoph Alt, Claudio Bruschini, Noemi Bührer, Edoardo Charbon, Kodai Kaneyasu, Tim Weber, Matthew Franks, Davide Sgalaberna   +9 more
doaj   +1 more source

Enhancing electrospray ionization efficiency for particle transmission through an aerodynamic lens stack

Journal of Synchrotron Radiation
This work investigates the performance of the electrospray aerosol generator at the European X-ray Free Electron Laser (EuXFEL). This generator is, together with an aerodynamic lens stack that transports the particles into the X-ray interaction vacuum ...
Safi Rafie-Zinedine, Tej Varma Yenupuri, Lena Worbs, Filipe R. N. C. Maia, Michael Heymann, Joachim Schulz, Johan Bielecki   +6 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

A Maximum-Likelihood Approach to Single-Particle Image Refinement

Journal of Structural Biology, 1998
The alignment of single-particle images fails at low signal-to-noise ratios and small particle sizes, because noise produces false peaks in the cross-correlation function used for alignment. A maximum-likelihood approach to the two-dimensional alignment problem is described which allows the underlying structure to be estimated from large data sets of ...
openaire   +2 more sources

Rayleigh-scattering microscopy for tracking and sizing nanoparticles in focused aerosol beams

IUCrJ, 2018
Ultra-bright femtosecond X-ray pulses generated by X-ray free-electron lasers (XFELs) can be used to image high-resolution structures without the need for crystallization.
Max F. Hantke, Johan Bielecki, Olena Kulyk, Daniel Westphal, Daniel S. D. Larsson, Martin Svenda, Hemanth K. N. Reddy, Richard A. Kirian, Jakob Andreasson, Janos Hajdu, Filipe R. N. C. Maia   +10 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source