Results 91 to 100 of about 495,951 (309)

Single particle tracking uncertainties in ion imaging

, 2020
19 pages, 6 figures, submitted to Phys.
Burker, A., Bergauer, T., Hirtl, A., Irmler, C., Kaser, S., Knäusl, B., Pitters, F., Ulrich-Pur, F.   +7 more
openaire   +2 more sources

Comparing the Performance of Raman and Near-Infrared Imaging in the Prediction of the In Vitro Dissolution Profile of Extended-Release Tablets Based on Artificial Neural Networks

Pharmaceuticals, 2023
In this work, the performance of two fast chemical imaging techniques, Raman and near-infrared (NIR) imaging is compared by utilizing these methods to predict the rate of drug release from sustained-release tablets.
Dorián László Galata, Szilveszter Gergely, Rebeka Nagy, János Slezsák, Ferenc Ronkay, Zsombor Kristóf Nagy, Attila Farkas   +6 more
doaj   +1 more source

4D Scanning Transmission Ultrafast Electron Microscopy: Single-Particle Imaging and Spectroscopy [PDF]

, 2011
We report the development of 4D scanning transmission ultrafast electron microscopy (ST-UEM). The method was demonstrated in the imaging of silver nanowires and gold nanoparticles.
Ortalan, Volkan, Zewail, Ahmed H.
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Polarization-controlled single-particle scattering imaging spectroscopy using waveguide excitation

Optics Express, 2022
An imaging spectroscopic system that enables spatially-resolved detection of single-particle scattering with polarization-controlled waveguide excitation scheme is presented. The detected microscopic images of inhomogeneous nanostructures are recorded in a time sequence into a data cube based on a Michelson interferometer.
Wan-Shao Tsai, Li Shen, Yuan-Chih Hou, Tsong-Sheng Lay   +3 more
openaire   +2 more sources

Single molecule imaging with longer x-ray laser pulses [PDF]

, 2015
During the last five years, serial femtosecond crystallography using x-ray laser pulses has developed into a powerful technique for determining the atomic structures of protein molecules from micrometer and sub-micrometer sized crystals.
Caleman, Carl, Corso, Justine K., Martin, Andrew V., Quiney, Harry M., Timneanu, Nicusor   +4 more
core   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Structure determination using high-order spatial correlations in single-particle X-ray scattering

IUCrJ
Single-particle imaging using X-ray free-electron lasers (XFELs) is a promising technique for observing nanoscale biological samples under near-physiological conditions.
Wenyang Zhao, Osamu Miyashita, Miki Nakano, Florence Tama   +3 more
doaj   +1 more source

Start-to-end simulation of single-particle imaging using ultra-short pulses at the European X-ray Free-Electron Laser

IUCrJ, 2017
Single-particle imaging with X-ray free-electron lasers (XFELs) has the potential to provide structural information at atomic resolution for non-crystalline biomolecules.
Carsten Fortmann-Grote, Alexey Buzmakov, Zoltan Jurek, Ne-Te Duane Loh, Liubov Samoylova, Robin Santra, Evgeny A. Schneidmiller, Thomas Tschentscher, Sergey Yakubov, Chun Hong Yoon, Michael V. Yurkov, Beata Ziaja-Motyka, Adrian P. Mancuso   +12 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source