Results 261 to 270 of about 12,921,630 (316)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Decoding the regulatory genome: single-cell four-omics integration. [PDF]

Signal Transduct Target Ther
Kim H, Byun J, Kwon T.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Single-cell immune profiling of blood and thrombus in cancer-associated thrombosis. [PDF]

iScience
Zhou L, Xia Y, Chen B, Lin X, Yang HC, Yu CW.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

scGraphVerse: a modular workflow for single-cell gene network inference. [PDF]

Bioinform Adv
Cecere F, De Canditiis D, Carissimo A, Angelini C.   +3 more
europepmc   +1 more source

Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease. [PDF]

Science
Zhang Y, Lu X, Kunisky AK, Alam S, Tang J, Zhang R, Wang S, Zhang H, Baroudi J, Ichcho W, Jia D, Ghorbanikalateh S, Ghorbanikalateh S, Wang S, Bennett DA, Mathys H, Duan Z, Ma J.   +17 more
europepmc   +1 more source

The challenges of single cell transcriptomics on difficult human tissue: the placenta. [PDF]

NAR Genom Bioinform
Xenakis T, Hall GT, Moreno-Villena JJ, Hillman SL, Sanchez-Corrales YE, Castellano S.   +5 more
europepmc   +1 more source

ILF3 regulates erythroid differentiation: A single-cell transcriptomic analysis and cellular experiment. [PDF]

PLoS One
Wu X, Lu M, Jia W, Lin W, He Y.
europepmc   +1 more source

Molecular pathways for learning in the single-cell Stentor coeruleus. [PDF]

Curr Biol
Rajan DH, Albright A, Kim H, Diaz U, Hudnall Y, Steube N, Dey G, Liu T, Marshall WF.   +8 more
europepmc   +1 more source