Results 311 to 320 of about 1,169,281 (338)

A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity. [PDF]

Acta Pharmacol Sin
Zhu XY, Li QX, Kong Y, Huang KK, Wang G, Wang YJ, Lu J, Hua GQ, Wu YL, Ying TL.   +9 more
europepmc   +1 more source

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Development of a 99mTc-Labeled Single-Domain Antibody for SPECT/CT Assessment of HER2 Expression in Breast Cancer.

Molecular Pharmaceutics, 2021
Accurate determination of human epidermal growth factor receptor 2 (HER2) expression is essential for HER2-targeted therapy in patients with cancer. HER2 expression in a complex environment, such as in a heterogeneous tumor, makes the precise assessment ...
Lingzhou Zhao, Chang-cun Liu, Y. Xing, Jin He, J. O’Doherty, Wenhua Huang, Jinhua Zhao   +6 more
semanticscholar   +1 more source

Structure- and sequence-based design of synthetic single-domain antibody libraries.

Protein engineering, design & selection : PEDS, 2020
Single-domain antibody fragments known as VHH have emerged in the pharmaceutical industry as useful biotherapeutics. These molecules, which are naturally produced by camelids, share the characteristics of high affinity and specificity with traditional ...
A. M. Sevy, Ming-Tang Chen, Michelle Castor, Tyler Sylvia, H. Krishnamurthy, A. Ishchenko, C. Hsieh   +6 more
semanticscholar   +1 more source

Single-domain antibody C7b for address delivery of nanoparticles to HER2-positive cancers.

Nanoscale, 2020
Monoclonal antibodies (mAb) demonstrate great potential as immunotherapy agents for the treatment of diseases such as cancer as well as tagging for the targeted delivery of multicomponent therapeutic or diagnostic systems.
Yuri A. Vorotnikov, E. D. Novikova, A. Solovieva, D. Shanshin, A. Tsygankova, D. N. Shcherbakov, O. Efremova, M. Shestopalov   +7 more
semanticscholar   +1 more source

sdAb-DB: The Single Domain Antibody Database.

ACS Synthetic Biology, 2018
The Single Domain Antibody Database, or sdAb-DB, ( www.sdab-db.ca ) is the first freely available repository for single domain antibodies and related classes of proteins.
Emily E Wilton, Michael P. Opyr, Senthilkumar Kailasam, Ronja F Kothe, Hans-Joachim Wieden   +4 more
semanticscholar   +1 more source

The phase I clinical study of CART targeting BCMA with humanized alpaca-derived single-domain antibody as antigen recognition domain.

Journal of Clinical Oncology, 2019
2535 Background: Several phase I clinical trials already shown Chimeric antigen receptor T cells (CART) targeting BCMA has the promised effects to treat the relapsed/refractory (RR) multiple myeloma (MM), RRMM.
Lu Han, Quanli Gao, K. Zhou, Jian Zhou, B. Fang, Jishuai Zhang, Hongjian Li, Yongping Song   +7 more
semanticscholar   +1 more source

An overview of precision oncology basket and umbrella trials for clinicians

Ca-A Cancer Journal for Clinicians, 2020
Kristian Thorlund, Edward J Mills
exaly  

Worldwide Variations in Colorectal Cancer

Ca-A Cancer Journal for Clinicians, 2009
Ahmedin Jemal
exaly  

Nanobody affinity improvement: Directed evolution of the anti-ochratoxin A single domain antibody.

International Journal of Biological Macromolecules, 2020
Xuerou Wang, Qi Chen, Zhichang Sun, Yidan Wang, Benchao Su, Chenghui Zhang, Hongmei Cao, Xing Liu   +7 more
semanticscholar   +1 more source

Selective Hydrogenation over Supported Metal Catalysts: From Nanoparticles to Single Atoms

Chemical Reviews, 2020
Leilei Zhang, , Zhang Tao
exaly