Results 121 to 130 of about 17,695,032 (262)
Single Event Rates for Devices Sensitive to Particle Energy
, 2012 Single event rates (SER) can include contributions from low-energy particles such that the linear energy transfer (LET) is not constant. Previous work found that the environmental description that is most relevant to the low-energy contribution to the ...
Scheick, L. Z. +2 more
core
Event-free survival from major arrhythmic events.
Event free survival at 96 months from major arrhythmic event, defined as sudden cardiac death, cardiac arrest due to ventricular fibrillation, sustained ventricular tachycardia lasting ≥30s or causing hemodynamic collapse in A.
Laura De Michieli (17487254) +6 more
core +1 more source
Independent Single Event Upset Testing of the Microsemi RTG4: Preliminary Data [PDF]
, 2016 We present an independent investigation of heavy-ion single event effect data for the Microsemi RTG4 field programmable gate array (FPGA)
Seidleck, Christina +4 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Prediction of Single Event Effect in Inverter Circuit Based on Deep Learning
IEEE Journal of the Electron Devices SocietyFully Depleted Silicon on Insulator (FDSOI) technology can solve the short channel effect very effectively, with low power consumption, and low voltage, and can improve the subthreshold characteristics of the device.
Jin Huang +7 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2010 Field Programmable Gate Arrays, FPGAs, since their introduction on the market presented a very innovative way of implementing hardware designs. The fundamental property of these integrated circuits is the capability of a user's customization after manufacturing.
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source