Results 181 to 190 of about 853,970 (265)

The impact of low-carbon city pilot policies on urban energy intensity. [PDF]

Front Public Health
Qian Y, Hu J, Guo B, Liu T, Hu H.
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Educational Escape Rooms for Infection Prevention and Patient Safety Training in Medical and Nursing Education: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Thind A, Aggarwal N, Pisudde PM.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Impact of heated tobacco products on biomarkers of potential harm and adverse events: a systematic review and meta-analysis. [PDF]

Tob Control
Braznell S, Dance S, Hartmann-Boyce J, Gilmore A.   +3 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

CRT-Estimands Framework: consensus based extension of the ICH E9(R1) addendum for cluster randomised trials.

BMJ
Kahan BC, Bretz F, Copas A, Harhay MO, Collins GS, Bahti M, Bi D, Campbell MK, Courtright KR, Feeney T, Forbes AB, Garg AX, Halpern SD, Heagerty PJ, Hemming K, Hopewell S, Hughes JP, Murray DM, Ross JS, Stewart D, Taljaard M, Ukoumunne OC, Auriemma CL, Li F.   +23 more
europepmc   +1 more source

Perceived Stress and Subjective Happiness in Medical Students Before and After a Wellness Speaker Session. [PDF]

Cureus
Marupudi S, Hensley J, Gullapalli S, Sta Maria D, Anand N.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Magmaris bioresorbable magnesium scaffold in acute coronary syndromes: a systematic review and meta-analysis. [PDF]

Front Cardiovasc Med
Wölbert S, Escrihuela-Branz PFF, Kühne SG, Patrignani A, Chiarito M, Torzewski J, Raake PWJ, Bongiovanni D.   +7 more
europepmc   +1 more source