Results 181 to 190 of about 71,811 (209)

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Silanes to Silatranes: Robust Functionalization for Single-Molecule Force Spectroscopy. [PDF]

Chembiochem
Courtney TD, Hatchell CB, O X, Jacobson DR.   +3 more
europepmc   +1 more source

Bypassing Heteronuclear MRI: Metal‐Free Organosilicon Nanotracers for Background‐Free Hotspot 1H Imaging on Clinical Hardware

Advanced Science, EarlyView.
Organosilicon micelles enable background‐free molecular magnetic resonance imaging (MRI) while remaining fully compatible with standard proton (1H) hardware. By exploiting a spectrally silent 1H window at ∼0 ppm, the silicone nanotracer allows hotspot detection by 1H chemical‐shift imaging (CSI) without metals or heteronuclei, enabling direct overlay ...
Martin Orsagh, Dominik Havlicek, Andrea Galisova, Ondrej Sedlacek, Daniel Jirak   +4 more
wiley   +1 more source

Super-resolution microscopy: revolutionizing life sciences through advanced resolution. [PDF]

Biophys Rep
Luo S, Dong Y, Gu L, Ji W.
europepmc   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Microfluidic diffusional sizing in bioanalysis and biosensing.

Lab Chip
Bauernhofer L, Baron J, Keller S, Krainer G.   +3 more
europepmc   +1 more source

Development of ultrafast single fluorescent-molecule imaging and its application to unravel plasma membrane structure and function in live cells. [PDF]

Biophys Physicobiol
Fujiwara T, Kusumi A.
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Advancement of Peptide-PAINT: Applications and Current Challenges in Super-Resolution Imaging. [PDF]

Small Sci
Behera DP, Sonar R, Ghosh A, Maity BK.
europepmc   +1 more source

Ligand-tuned extracellular domain dynamics are correlated with signaling states in an adhesion GPCR. [PDF]

Sci Adv
Cechova K, Bandekar SJ, Kordon SP, Foroutan M, Leon K, Siffer G, Schamber MR, Luiso M, Araç D, Vafabakhsh R.   +9 more
europepmc   +1 more source