Results 251 to 260 of about 71,132 (292)

Regulation of Pfh1 helicase activity by nucleic acid interactions and mitochondrial SSB. [PDF]

Proc Natl Acad Sci U S A
Ortiz-Rodríguez M, Singh SP, Cao-García FJ, Galletto R, Ibarra B.   +4 more
europepmc   +1 more source

Molecular Engineering Mediated Interfacial Assembly as an Artificial Extracellular Matrix Remolds Bacteria With Enhanced Abiotic Resilience

Advanced Science, EarlyView.
A biomimetic artificial extracellular matrix is assembled directly on Pseudomonas fluorescens by co‐assembling amyloid‐like lysozyme and alginate at the cell surface. This conformal nanocoating acts as both a hydration buffer and a physiological priming layer, markedly enhancing desiccation tolerance, seed adhesion, storage stability, and biocontrol ...
Yuanyuan Wang, Zili Jia, Yang Li, Qitao Wang, Shuai Hou, Lei Liu   +5 more
wiley   +1 more source

Lipids challenge ligands to control receptors. [PDF]

Elife
Wollman AJM.
europepmc   +1 more source

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, EarlyView.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source

A Wireless 3D Magneto‐Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

Advanced Science, EarlyView.
An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li, Li Peng, Laiya Lu, Yingying Wang, Xiaolei Chen, Feng Yin, Cuijun Deng, Yu Cheng   +7 more
wiley   +1 more source

The protocadherin-15-LHFPL5 tip link complex is a heterotetrameric assembly in hair cell stereocilia. [PDF]

Biophys J
Clark S, Mitra J, Elferich J, Goehring A, Ge J, Ha T, Gouaux E.   +6 more
europepmc   +1 more source

Monitoring Membrane Protein Folding Assisted by Insertases and Translocases Using AFM-Based Single-Molecule Force Spectroscopy. [PDF]

Chem Rev
Serdiuk T, Thoma J, Müller DJ.
europepmc   +1 more source

Photophysics of Organic Fluorophore Photobluing and Its Applications in Fluorescence and Super-Resolution Microscopy. [PDF]

Acc Chem Res
Son JB, Ahn Y, Yeou S, Cho Y, An HJ, Lee C, Lee NK.   +6 more
europepmc   +1 more source

How enzymes make the right choice during biosynthesis. [PDF]

Elife
Ramírez AS, Perez C.
europepmc   +1 more source

Single-molecule tracking of DNMT1 in living cells reveals its cell cycle dynamics and its redistribution upon drug treatment. [PDF]

Nucleic Acids Res
Lee ES, Tommer ER, Rothman PB, Middleton SV, Youmans DT, Cech TR.   +5 more
europepmc   +1 more source