Results 21 to 30 of about 7,224,188 (257)
Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A
Retrovirology, 2019 Background Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site.
Wang Peng +9 more
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Serotonin: an overlooked regulator of endocytosis and endosomal sorting?
Biology Open, 2022 Serotonin is a neurotransmitter and a hormone that is typically associated with regulating our mood. However, the serotonin transporter and receptors are expressed throughout the body, highlighting the much broader, systemic role of serotonin in ...
Gregory Redpath, Nikita Deo
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Nature Communications, 2018 Endocytosis of T cell receptors (TCR) and their polarized recycling back to the plasma membrane is crucial for T cell activation; however, the underlying mechanisms remain unclear.
Ewoud B. Compeer +15 more
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Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis
eLife, 2018 Uncoating of the metastable HIV-1 capsid is a tightly regulated disassembly process required for release of the viral cDNA prior to nuclear import. To understand the intrinsic capsid disassembly pathway and how it can be modulated, we have developed a ...
Chantal L Márquez +10 more
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, 2022 Paper 686204This paper presents a stochastic theory for the interpretation of photon counting histograms in fluorescence fluctuation spectroscopy (FFS). New concepts of an effective volume and a single molecule probability distribution are introduced to ...
Greiner, B., Ackermann, J., Mathis, H.
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Flotillins promote T cell receptor sorting through a fast Rab5–Rab11 endocytic recycling axis
Nature Communications, 2019 Internalized receptors are recycled back to the cell surface, but their precise mechanisms are unclear. Here, the authors show that the flotillin membrane proteins may regulate the transfer of internalized T cell receptors into Rab5 and Rab11-positive ...
Gregory M. I. Redpath +8 more
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Identification of binding mechanisms in single molecule-DNA complexes [PDF]
, 2003 Eckel R, Ros R, Ros A, Wilking SD, Sewald N, Anselmetti D. Identification of binding mechanisms in single molecule-DNA complexes. Biophysical journal. 2003;85(3):1968-1973.Changes in the elastic properties of single deoxyribonucleic acid (DNA) molecules ...
Anselmetti, Dario +14 more
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Single-molecule chemical denaturation of riboswitches [PDF]
, 2013 To date, single-molecule RNA science has been developed almost exclusively around the effect of metal ions as folding promoters and stabilizers of the RNA structure.
St-Pierre, Patrick +14 more
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Frontiers in Cellular Neuroscience, 2022 Depression and anxiety are common, debilitating psychiatric conditions affecting millions of people throughout the world. Current treatments revolve around selective serotonin reuptake inhibitors (SSRIs), yet these drugs are only moderately effective at ...
Nikita Deo, Gregory Redpath
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The nature of condensed single molecules : local electronic and mechanical characteristics [PDF]
, 2014 In order to advance the performance of molecule based electronic devices a detailed and fundamental knowledge about the underlying physical aspects is mandatory.
Fremy, Sweetlana Deva
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