Results 71 to 80 of about 4,995,337 (307)

Effect of periodic vibration-isolation piles on soil vibration in deep-buried tunnels of suburban railways

Science Progress
This study aims to investigate the impact of isolation piles on soil vibrations in the environment surrounding suburban railways. Initially, a comprehensive numerical model of the train was established to simulate the wheel-rail interaction forces, which
Shusen Cao, Dong Li, Jili Yin, Qin Xu, Dongdong Qian, Chao Chen, Hongkai Wang, Lunzheng Zhang, Xiangdong Shi, Futong Wang   +9 more
doaj   +1 more source

An Investigation into the Lateral Bearing Performance of a Single Pile Embedded at a Three-Dimensional Asymmetric Local Scour Site Using the Modified Strain Wedge Model

Applied Sciences
The scouring effect is widely acknowledged as a primary contributor to the weakening in the bearing performance of offshore piles; it often results in asymmetric scour patterns around the pile.
Songyang Wang, Jianjun Ma, Chaosheng Wang, Fengjun Liu, Da Li   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Failure mechanism and setback distance of single pile subjected to normal faulting

Yantu gongcheng xuebao, 2017
Field case studies after earthquake show that pile foundation can be severely damaged by bedrock fault movement. The failure mechanism of this type of foundation damage is not yet fully understood.
CAI Qi-peng 1, NG C. W. W. 2, CHEN Xing-xin 1, GUO Li-qun 1
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Analytical method for single pile under V-H-M combined loads in sand

Yantu gongcheng xuebao, 2017
The large-diameter monopiles of offshore wind turbines are always subjected to multiaxial loads. The design criteria for the vertical and lateral bearing behaviors of piles are designed independently, while lots of tests show that the vertical load has a
MU Lin-long 1, 2, KANG Xing-yu 1, 2, LI Wan 1, 2
doaj   +1 more source

Updating reliability of single piles and pile groups by load tests

Computers and Geotechnics, 2016
Pile load tests are used to refine designs and for quality assurance. They can also be used to verify the reliability of piles and pile groups. Stochastic methods have previously been developed to verify the reliability of single piles. A general stochastic method to verify the reliability of pile groups is developed in this paper.
Jinsong Huang, Richard Kelly, Dianqinq Li, Chuangbing Zhou, Scott Sloan   +4 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Comparison of horizontal push-pile model tests between non-beam double-row anti-slide piles and single-row anti-slide piles

Shuiwen dizhi gongcheng dizhi
In large-scale landslide control engineering design, the selection of anti-slide pile support is a critical design consideration. To investigate the effectiveness of double-row anti-slide piles compared to single-row reinforcement for slopes, this study ...
Ke TANG, Da ZHENG, Rusong CHENG
doaj   +1 more source