Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Development of LRFD Procedures for Bridge Pile Foundations in Iowa: Volume II: Field Testing of Steel Piles in Clay, Sand, and Mixed Soils and Data Analysis, September 2011 [PDF]
, 2011 In response to the mandate on Load and Resistance Factor Design (LRFD) implementations by the Federal Highway Administration (FHWA) on all new bridge projects initiated after October 1, 2007, the Iowa Highway Research Board (IHRB) sponsored these ...
core
The Development and Testing of an Instrumented Open-Ended Model Pile [PDF]
, 2012 This paper describes the development of a model instrumented open-ended (pipe) pile. The importance of model geometry and separating the shaft, annular and plug load, and horizontal effective stresses is discussed.
Igoe, David +2 more
core +1 more source
Research on the bearing behavior of single pile in self-weight collapsible loess areas. [PDF]
PLoS One, 2023 Gao D, Zhao K, Ma B, Han Z, Fan J.
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Some observations on statnamic pile testing [PDF]
, 2006 Limited guidance on usage and methodology is currently available to engineers for the most common rapid load pile test, known as Statnamic. In order to improve the analysis of Statnamic testing in clay soils a full-scale instrumented auger bored pile was
Brown, M. J.; id_orcid, Hyde, A. F. L.
core +1 more source
Experimental study on the impact load characteristics of a single-row pile dam against debris flow
Geomatics, Natural Hazards & RiskA single-row pile dam is a type of rigid debris flow barrier structure. In order to reveal the mutual interaction effects between debris flow and a single-row pile dam and the distribution law of debris flow impact forces, an analysis of the correlation ...
Hao Sun +5 more
doaj +1 more source
Finite element simulation study on vertical bearing characteristics of single pile with ram-compacted bearing sphere. [PDF]
PLoS One, 2023 Bai L, Gong S, Xu L, Bai X, Huang Z.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source