Results 91 to 100 of about 317,336 (296)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Palsgraf Revisited (Again) [PDF]

, 2007
[Excerpt] “A funny thing happened at the 2005 meeting of the American Law Institute in Philadelphia. With hardly a thought as to the profundity—and probable futility—of its act, the assemblage bulldozed one of the enduring nuggets of common law wisdom to
Little, Joseph W.
core   +1 more source

Beam-beam effects in the high-pile-up tests of the LHC

, 2014
Investigating the beam-beam limit in the LHC is of great importance, since identifying its source is crucial for the luminosity optimization scenario. Several experiments were carried out to search for this limit and check whether it is dominated by the ...
Trad, G.
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Comparison of horizontal push-pile model tests between non-beam double-row anti-slide piles and single-row anti-slide piles

Shuiwen dizhi gongcheng dizhi
In large-scale landslide control engineering design, the selection of anti-slide pile support is a critical design consideration. To investigate the effectiveness of double-row anti-slide piles compared to single-row reinforcement for slopes, this study ...
Ke TANG, Da ZHENG, Rusong CHENG
doaj   +1 more source

Soil-Pile Interface Model for Axially Loaded Single Piles

Soils and Foundations, 1999
On the basis of the observed experimental behavior of axially loaded friction piles driven in soft clays, a soil-pile interface model is proposed using the basic rheological units: springs, dashpots and sliding elements. All the mass of soil affected by the presence of the pile is concentrated in a ring of infinitesimal width.
Eduardo Rojas, Celestino Valle, Miguel P. Romo   +2 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Research on the bearing behavior of single pile in self-weight collapsible loess areas. [PDF]

PLoS One, 2023
Gao D, Zhao K, Ma B, Han Z, Fan J.
europepmc   +1 more source

The $\star$-operator and Invariant Subtraction Games

, 2010
We study 2-player impartial games, so called \emph{invariant subtraction games}, of the type, given a set of allowed moves the players take turn in moving one single piece on a large Chess board towards the position $\boldsymbol 0$.
Larsson, Urban
core