Results 41 to 50 of about 404,024 (253)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Implementation of single-qubit gates with two rotations around axes in a plane

APL Quantum
Typical experimental implementations of single-qubit gates involve two or three fixed rotation axes and up to three rotation steps. In this work, we prove that if the rotation axes can be tuned arbitrarily in a fixed plane, then two rotation steps are ...
Yun-Pil Shim, Edward Takyi, Jianjia Fei, Sangchul Oh, Xuedong Hu, Mark Friesen   +5 more
doaj   +1 more source

Bidirectional optical rotation of cells

AIP Advances, 2017
Precise and controlled rotation manipulation of cells is extremely important in biological applications and biomedical studies. Particularly, bidirectional rotation manipulation of a single or multiple cells is a challenge for cell tomography and ...
Jiyi Wu, Weina Zhang, Juan Li
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Rotation Periods of Candidate Single Late-M Dwarfs in TESS

The Astronomical Journal
Recent studies suggest that the angular momentum evolution of late-M and brown dwarfs differs from the well-known spin-down evolution of hotter stars. Characterizing the distribution of rotation periods of these objects in the solar neighborhood can help
Samantha Lambier, Stanimir Metchev, Paulo Miles-Páez, Leslie Moranta, Dakota Wolfe, Joelene Hales, Jeffrey Martinovic   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Structures of the stator complex that drives rotation of the bacterial flagellum

Nature Microbiology, 2020
The bacterial flagellum is the prototypical protein nanomachine and comprises a rotating helical propeller attached to a membrane-embedded motor complex.
J. Deme, Steven Johnson, Owen N. Vickery, A. Aron, Holly Monkhouse, T. Griffiths, Rory Hennell James, B. Berks, J. Coulton, P. Stansfeld, S. Lea   +10 more
semanticscholar   +1 more source

Solution‐Processed Faraday Rotators Using Single Crystal Lead Halide Perovskites

Advanced Science, 2020
Lead halide perovskites (LHPs) have become a promising alternative for a wide range of optoelectronic devices, thanks to their solution‐processability and impressive optical and electrical properties. More recently, LHPs have been investigated in magneto‐
Randy P Sabatini, Chwenhaw Liao, Stefano Bernardi, Wenxin Mao, Matthew S. Rahme, Asaph Widmer‐Cooper, Udo Bach, Shujuan Huang, Anita W. Y. Ho‐Baillie, Girish Lakhwani   +9 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source