Results 211 to 220 of about 9,727,209 (283)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A comparative study of single-stage and dual-stage classification models for OPMDs. [PDF]

BMC Oral Health
Yu J, Huang R, Wang X, Zhang Y, Li Y, Ye Y, Ouyang M, Su W, Wen J, Zhang Z, Liu Q, Liu Z, Liu W.   +12 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Single-Stage Combined Embolization and Structural Allograft Reconstruction for Proximal Humerus Aneurysmal Bone Cysts in Children. [PDF]

Children (Basel)
Leiblein M, Frank J, Marzi I, Sommer K, Eichler K, Vogl T, Wagner N.   +6 more
europepmc   +1 more source

Single stage reconstruction of the missing breast

British Journal of Plastic Surgery, 1973
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Novel surgical technique for vestibular fistula: single-stage anorectoplasty without perineal incision using fistula inversion. [PDF]

J Surg Case Rep
Ikeda T, Goto S, Nagasaki E, Hashimoto M.   +3 more
europepmc   +1 more source

Comparative effectiveness of single-stage versus two-stage revision for hip prosthetic joint infection: emulation of the INFORM target trial using electronic health record data. [PDF]

Arch Orthop Trauma Surg
Zhang C, Li Y, Su C, Shen Y, Lu S.
europepmc   +1 more source

Clinical efficacy of membrane anatomy-based 3D laparoscopic partial nephrectomy in a single stage for the treatment of ruptured renal angiomyolipoma. [PDF]

Front Oncol
Xiao J, Zheng H, Liu Y, Chen Z, Luo F, Wu G, Ye S, Li P, Kang T, Luo H, Lai C, Ye D.   +11 more
europepmc   +1 more source