Results 71 to 80 of about 2,007,382 (285)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

HYPERSURFACE EXCEPTIONAL SINGULARITIES [PDF]

International Journal of Mathematics, 2001
This paper studies hypersurface exceptional singularities in [Formula: see text] defined by non-degenerate function. For each canonical hypersurface singularity, there exists a weighted homogeneous singularity such that the former is exceptional if and only if the latter is exceptional.
Ishii, Shihoko, Prokhorov, Yuri
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

PrimerEvalPy: a tool for in-silico evaluation of primers for targeting the microbiome

BMC Bioinformatics
Background The selection of primer pairs in sequencing-based research can greatly influence the results, highlighting the need for a tool capable of analysing their performance in-silico prior to the sequencing process. We therefore propose PrimerEvalPy,
Lara Vázquez-González, Alba Regueira-Iglesias, Carlos Balsa-Castro, Nicolás Vila-Blanco, Inmaculada Tomás, María J. Carreira   +5 more
doaj   +1 more source

Contact singularities

manuscripta mathematica, 2002
Comment: 11 pages, Latex, uses diagrams.tex of P. Taylor, see e.g. ftp://ftp.dante.de/pub/tex/macros/generic/diagrams/taylor/diagrams.tex.
Campana, Frédéric, Flenner, Hubert
openaire   +2 more sources

NAKED SINGULARITY EXPLOSION [PDF]

The Ninth Marcel Grossmann Meeting, 2000
6 pages, 3 figures, Accepted for Publication in Phys. Rev.
Harada, Tomohiro, Iguchi, Hideo, Nakao, Ken-ichi   +2 more
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Exo-chirality of the α-helix

Nature Communications
The structure of helical polymers is dictated by the molecular chirality of their monomer units. Particularly, macromolecular helices with monomer sequence control have the potential to generate chiral topologies.
Jose M. Martínez-Parra, Rebeca Gómez-Ojea, Geert A. Daudey, Martin Calvelo, Hector Fernández-Caro, Javier Montenegro, Julian Bergueiro   +6 more
doaj   +1 more source

SINGULAR HERMITIAN METRICS WITH ISOLATED SINGULARITIES

Nagoya Mathematical Journal, 2022
AbstractIn this paper, we study the coherence of a higher rank analogue of a multiplier ideal sheaf. Key tools of the study are Hörmander’s $L^2$ -estimate and a singular version of a Demailly–Skoda-type result.
openaire   +3 more sources