Results 71 to 80 of about 117,839 (311)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Higher-Order Energy Expansions and Spike Locations [PDF]
, 2004 We consider the following singularly perturbed semilinear elliptic problem: (I)\left\{ \begin{array}{l} \epsilon^{2} \Delta u - u + f(u)=0 \ \ \mbox{in} \ \Omega, \\ u>0 \ \ \mbox{in} \ \ \Omega \ \ \mbox{and} \ \frac{\partial u}{\partial \nu}
Winter, M, Wei, J
core +1 more source
Singularities at real points of ? space
General Relativity and Gravitation, 1980 In the presence of gravitational radiation, there are ordinarily no shear-free slices of null infinity. A four-complex-dimensional set of shear-free slices of complexified null infinity do exist. They comprise the manifold ℋ space. In general, there are no preferred real subspaces ofℋ space associated with slices of real null infinity.
Tod, K, Winicour, J
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
On Singular Points of Equations of Mechanics
Doklady Mathematics, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Approche variationnelle de la fonction rang : relaxation convexe, sous-différentiation généralisée, régularisation-approximation de Moreau [PDF]
, 2013 Dans ce mémoire de these, nous étudions la fonction rang du point de vue variationnel. La raison pour laquelle nous nous intéressons à cette fonction est qu'elle apparaît comme une fonction objectif (ou comme fonction contrainte) dans divers problèmes d ...
Le, Hai Yen
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Singular Spectrum Analysis: Methodology and Comparison [PDF]
In recent years Singular Spectrum Analysis (SSA), used as a powerful technique in time series analysis, has been developed and applied to many practical problems. In this paper, the performance of the SSA technique has been considered by applying it to a
Hassani, Hossein
core +1 more source
Multi-Peak Solutions for a Wide Class of Singular Perturbation Problems [PDF]
, 1999 In this paper we are concerned with a wide class of singular perturbation problems arising from such diverse fields as phase transitions, chemotaxis, pattern formation, population dynamics and chemical reaction theory.
Winter, M +3 more
core