Results 81 to 90 of about 6,024,846 (308)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Description of the structure of singular spectrum for Friedrichs model operator near singular point
International Journal of Mathematics and Mathematical Sciences, 2001 The study of the point spectrum and the singular continuous one is reduced to investigating the structure of the real roots set of an analytic function with positive imaginary part M(λ).
Serguei I. Iakovlev
doaj +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Anisotropic media with singular slowness surfaces
Геофизический журналIt is proved that if an anisotropic medium has an open set of singular directions, then this medium has two slowness surfaces that completely coincide. The coinciding slowness surfaces form one double singular slowness surface.
Yu.V. Roganov, A. Stovas, V.Yu. Roganov
doaj +1 more source
Separatrices and singular points [PDF]
Aequationes Mathematicae, 1978 A new definition of separatrix is introduced and the theory developed is applied to the study of the topological structure of singular points. Each component of the complement of the separatrix set in a neighborhood of an isolated singular point is shown to satisfy one of seven types of behavior.
openaire +2 more sources
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Учёные записки Казанского университета: Серия Физико-математические наукиThis article analyzes the inhomogeneous Hilbert boundary value problem for an upper half-plane with the finite index and boundary condition on the real axis for one generalized Cauchy–Riemann equation with a singular point on the real axis.
P. L. Shabalin, R. R. Faizov
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HEEGAARD FLOER HOMOLOGY AND RATIONAL CUSPIDAL CURVES
Forum of Mathematics, Sigma, 2014 We apply the methods of Heegaard Floer homology to identify topological properties of complex curves in $\mathbb{C}P^{2}$. As one application, we resolve an open conjecture that constrains the Alexander polynomial of the ...
MACIEJ BORODZIK, CHARLES LIVINGSTON
doaj +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source