Results 71 to 80 of about 75,924 (265)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
Rigidez de una superficie con puntos singulares
Revista de Matemática: Teoría y Aplicaciones, 2009 The infinitesimal isometric deformations of a type of surface with singular points are considered and a sufficient condition of rigidity of such surfaces is demonstrated. Keywords: Surface with singular points, Gauss formula, typical number.
Elena Chkryl
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Singular Cauchy Problem for a Nonlinear Fractional Differential Equation
MathematicsThe paper studies a nonlinear equation including both fractional and ordinary derivatives. The singular Cauchy problem is considered. The theorem of the existence of uniqueness of a solution in the neighborhood of a fixed singular point of algebraic type
Victor Orlov
doaj +1 more source
Separatrices and singular points [PDF]
Aequationes Mathematicae, 1978 A new definition of separatrix is introduced and the theory developed is applied to the study of the topological structure of singular points. Each component of the complement of the separatrix set in a neighborhood of an isolated singular point is shown to satisfy one of seven types of behavior.
openaire +2 more sources
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Вестник Северо-Кавказского федерального университета, 2022 The work describes the construction, training and testing of an artificial neural network (ANN) designed for determining whether an arbitrary point a seven-dimensional projective complex spacebelongs to the variety of singular points of the first kind ...
Anatoliy Nicolaevich Makoha +1 more
doaj