Results 51 to 60 of about 64,352 (312)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Uniqueness of a very singular solution to nonlinear degenerate parabolic equations with absorption for Dirichlet boundary condition

open access: yesElectronic Journal of Differential Equations, 2016
We prove the existence and uniqueness of singular solutions (fundamental solution, very singular solution, and large solution) of quasilinear parabolic equations with absorption for Dirichlet boundary condition. We also show the short time behavior of
Nguyen Anh Dao
doaj  

On the numerical solution of the multidimensional singular integrals and integral equations, used in the theory of linear viscoelasticity

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1988
In the present report, we investigate the formulation, for the numerical evaluation of the multidimensional singular integrals and integral equations, used in the theory of linear viscoelasticity. Some simple formulas are given for the numerical solution
E. G. Ladopoulos
doaj   +1 more source

Singularity Analysis for the Existing Closed-Form Solutions of the Hand-Eye Calibration

open access: yesIEEE Access, 2018
In this paper, a class of singular phenomenon is first found for the existing closed-form solutions of the hand-eye calibration problem with the form AiX = XBi when the angles corresponding to rotational parts of Ai and Bi are near or equal to π ...
Huajian Song   +3 more
doaj   +1 more source

A Solution Theory for Quasilinear Singular SPDEs [PDF]

open access: yesCommunications on Pure and Applied Mathematics, 2019
AbstractWe give a construction allowing us to build local renormalized solutions to general quasilinear stochastic PDEs within the theory of regularity structures, thus greatly generalizing the recent results of [1, 5, 11]. Loosely speaking, our construction covers quasilinear variants of all classes of equations for which the general construction of ...
Gerencsér, M, Hairer, M
openaire   +6 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Twin Solutions to Singular Dirichlet Problems

open access: yesJournal of Mathematical Analysis and Applications, 1999
The authors consider the Dirichlet second-order boundary value problem \[ y''+ \phi(t)[g(y(t))+ h(y(t))]= 0,\quad 0< t< 1,\quad y(0)= y(1)= 0,\tag{1} \] and establish the existence of two solutions \(y_1,y_2\in C[0,1]\cap C^2(0, 1)\) with \(y_1> 0\), \(y_2> 0\) on \((0,1)\). The nonlinearity in (1) may be singular at \(y= 0\), \(t= 0\) and/or \(t= 1\).
Agarwal, R.P., O'Regan, D.
openaire   +3 more sources

Exact solutions and singularities in string theory [PDF]

open access: yesPhysical Review D, 1994
We construct two new classes of exact solutions to string theory which are not of the standard plane wave or gauged WZW type. Many of these solutions have curvature singularities. The first class includes the fundamental string solution, for which the string coupling vanishes near the singularity.
Arkady A. Tseytlin, Gary T. Horowitz
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

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