Results 121 to 130 of about 1,311,541 (283)

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Use of machine learning and Poincaré density grid in the diagnosis of sinus node dysfunction caused by sinoatrial conduction block in dogs

Journal of Veterinary Internal Medicine
Background Sinus node dysfunction because of abnormal impulse generation or sinoatrial conduction block causes bradycardia that can be difficult to differentiate from high parasympathetic/low sympathetic modulation (HP/LSM).
Wyatt Hutson Flanders, N. Sydney Moïse, Niels F. Otani   +2 more
doaj   +1 more source

SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation

Regenerative Therapy, 2022
Introduction: Dysfunction of the sinoatrial node (SAN) cells causes arrhythmias, and many patients require artificial cardiac pacemaker implantation. However, the mechanism of impaired SAN automaticity remains unknown, and the generation of human SAN ...
Takayuki Wakimizu, Kumi Morikawa, Kenta Fukumura, Tetsuo Yuki, Takashi Adachi, Yasutaka Kurata, Junichiro Miake, Ichiro Hisatome, Motokazu Tsuneto, Yasuaki Shirayoshi   +9 more
doaj  

An integrated platform for 2‐D and 3‐D optical and electrical mapping of arrhythmias in Langendorff‐perfused rabbit hearts

The Journal of Physiology, EarlyView.
Abstract figure legend Integrated multimodal platform for panoramic cardiac mapping in isolated heart experiments. On the left, an image of the experimental setup during data acquisition showing a Langendorff‐perfused rabbit heart surrounded by three optical cameras (CAM A, B and C) positioned 120° apart, each coupled with high‐power LEDs for panoramic
Jimena Siles, Vinícius Silva, Tainan Neves, Italo Sandoval, Angélica Quadros, Giovanni Weber, Óscar Barquero, Ilija Uzelac, João Salinet   +8 more
wiley   +1 more source

Análise comparativa entre a vascularização arterial ventricular e do nó sinoatrial em corações de cães Comparative analysis between both ventricular and sinoatrial node arterial vascularization in heart of dogs

Pesquisa Veterinária Brasileira, 2013
Utilizamos nesta pesquisa 40 corações de cães adultos, machos e fêmeas, de idades variadas, que não portavam nenhuma afecção cardíaca. Os corações tiveram as artérias coronárias injetadas, separadamente, com Neoprene Látex 450, corado com pigmento ...
Caio Biasi, Vicente Borelli, Rodrigo F. Prazeres, Phelipe O. Favaron, Valdir Pavanelo Junior, Thiago P.A. Aloia, Pedro P. Bombonato   +6 more
doaj  

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells [PDF]

, 2017
Background: Human induced pluripotent stem cells (hiPSC) harbor the potential to differentiate into diverse cardiac cell types. Previous experimental efforts were primarily directed at the generation of hiPSC-derived cells with ventricular cardiomyocyte ...
Darche, Fabrice F., Draguhn, Andreas, Geschwill, Pascal, Greber, Boris, Katus, Hugo A., Koenen, Michael, Müller-Decker, Karin, Rivinius, Rasmus, Schweizer, Patrick A., Seyler, Claudia, Thomas, Dierk, Ullrich, Nina D., Utikal, Jochen   +12 more
core   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Rotating Frame Relaxation Time Mapping for the Visualization of the Sinoatrial Node Without Contrast Agent

NMR in Biomedicine, Volume 38, Issue 8, August 2025.
In this study, we have found that SAN structure displays higher relaxation time compared to remote myocardium. TRAFF2 and T1ρ are highly correlated with SAN size determined by histology. TRAFF2 and T1ρ relaxation time maps are feasible non‐invasive methods to visualize SAN structure.
Yi Li, Victor Casula, Tarja Huhta, Sarah Mailhiot, Katja Tolkkinen, Jouni Karjalainen, Timo Liimatainen   +6 more
wiley   +1 more source

Activity of cholinesterases of blood and heart in rats of different sex and age during muscular loads and hypokinesia [PDF]

The activity of acetylcholinesterase (Ache) and butyrilcholinesterase (Bche) in the blood and the heart of 3 and 13 month old control male rats is considerably lower than in female rats.
Antonova, G. A., Rozanova, V. D.
core   +1 more source

ADENYLYL CYCLASE TYPE 9: REGULATION AND CARDIAC FUNCTION [PDF]

, 2018
Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction
Baldwin, Tanya A., Baldwin, Tanya A.
core   +1 more source