Results 111 to 120 of about 10,498 (222)

Tirzepatide and Cardiovascular Outcomes: A Narrative Review of Mechanisms, Efficacy and Implications for Heart Failure Management

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Integrated framework for tirzepatide in HFpEF management. Through metabolic, haemodynamic, structural and anti‐inflammatory pathways, tirzepatide modifies the disease trajectory of HFpEF, leading to improvements in symptoms, functional capacity and reduction in HF events.
Hamza A. Abdul‐Hafez, Ameer Awashra, Sosana Bdir, Sarah Saife, Qasem Salah, Mohammed Barbarawi, Thabet Swaileh, Ahmed Emara, Mohamed S. Elgendy, Abdalhakim Shubietah   +9 more
wiley   +1 more source

What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]

, 2012
Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Benyhe, Sándor, Boyett, Marc, Dobrzynski, Halina, Dézsi, László, Erdélyi, Lajos, Papp, Gyula, Szalontai, Balázs, Szüts, Viktória, Varró, András, Vágvölgyi, Csaba, Zhang, Henggui, Ötvös, Ferenc   +11 more
core  

Age-dependent electrocardiographic changes in Pgc-1β deficient murine hearts. [PDF]

, 2018
Increasing evidence implicates chronic energetic dysfunction in human cardiac arrhythmias. Mitochondrial impairment through Pgc-1β knockout is known to produce a murine arrhythmic phenotype.
Akar, Antzelevitch, Arany, Bhuiyan, Billman, Boukens, Bovo, Brown, Brubaker, Bukowska, Chilton, Dai, Danik, Davies, Deo, Gazoti Debessa, Goldbarg, Gollob, Gurung, Huss, Jeevaratnam, Jeevaratnam, Jeevaratnam, Jeevaratnam, Jones, Kabunga, King, Kucharska-Newton, Lai, Lehman, Lelliott, Lin, Lin, Liu, Martin, Massumi, Mitchell, Mootha, Ning, Nisbet, Smyth, Sonoda, Sovari, Sullivan, Terentyev, Wang, Wu, Xie, Yan, Zhang, Zhang, Zoni-Berisso   +51 more
core   +1 more source

Energy Metabolism Under Stress: Late‐Stage Leigh Syndrome Reveals Profound Cardiometabolic Perturbations in Ndufs4 KO Mice

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
Cardiac bioenergetic and metabolic perturbations in late‐stage Leigh syndrome. Whole‐body NDUFS4 loss severely impairs cardiac complex I activity and respiration, shifting reliance to complex II and reducing glycolytic, TCA, and amino acid‐derived energy‐generating substrates in the heart.
Karin Terburgh, Nastassja Sweeney, Roan Louw   +2 more
wiley   +1 more source

Ivabradine: a preliminary observation for a new terapeutic role in patients with multiple organ dysfunction syndrome [PDF]

, 2014
[No abstract ...
De Santis, V, Frati, G, Greco, E, Tritapepe, L   +3 more
core   +1 more source

Subcutaneous nerve activity is more accurate than heart rate variability in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction [PDF]

, 2015
BACKGROUND: We recently reported that subcutaneous nerve activity (SCNA) can be used to estimate sympathetic tone. OBJECTIVE: The purpose of this study was to test the hypothesis that left thoracic SCNA is more accurate than heart rate variability (HRV)
Chan, Yi-Hsin, Chen, Lan S., Chen, Peng-Sheng, Han, Seongwook, Lin, Shien-Fong, Shen, Changyu, Tsai, Wei-Chung   +6 more
core   +2 more sources

Generation of an iPSC cell line (VANYHHi001-A) from a patient with cardiac arrythmias carrying CACNA1D, SCN5A, and DSP variants

Stem Cell Research
Progressive cardiac conduction defect often associated with variants in sodium voltage-gated channel SCN5A gene and variants in the L-type calcium voltage-gated channel CACNA1D gene are implicated in sinoatrial node dysfunction.
Yvonne Sleiman, Jean-Baptiste Reisqs, Reina Bianca Tan, Frank Cecchin, Mohamed Chahine, Mohamed Boutjdir   +5 more
doaj   +1 more source

Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking

Frontiers in Physiology, 2014
Normal heart rhythm (sinus rhythm) depends on regular activity of the sinoatrial node (SAN), a heterogeneous collection of specialized myocytes in the right atrium.
Sathya D Unudurthi, Roseanne M Wolf, Thomas eHund, Thomas eHund   +3 more
doaj   +1 more source

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node:L-type ICa, IKr, If, and Na-Ca exchange [PDF]

, 2015
The atrioventricular node (AVN) is a key component of the cardiac pacemaker-conduction system. This study investigated the electrophysiology of cells isolated from the AVN region of adult mouse hearts, and compared murine ionic current magnitude with ...
Cheng, Hongwei, Choisy, Stéphanie C, Hancox, Jules C, James, Andrew F, Orchard, Clive H   +4 more
core   +2 more sources

Use of antiarrhythmic drugs in elderly patients [PDF]

, 2013
Human aging is a global issue with important implications for current and future incidence and prevalence of health conditions and disability. Cardiac arrhythmias, including atrial fibrillation, sudden cardiac death, and bradycardia requiring pacemaker ...
Lee, Hon-Chi, Lee, Kristin Tin-Wai, Shen, Win-Kuang   +2 more
core   +1 more source