Results 91 to 100 of about 37,091 (294)

Association of DPP4 with esophageal stricture progression and the Hippo‐YAP pathway

Animal Models and Experimental Medicine, EarlyView.
This study establishes a comprehensive translational platform for esophageal stricture (ES) research by integrating a novel rat model with clinically relevant porcine validation. This study identifies DPP4 as a gene of interest associated with ES following endoscopic submucosal dissection, demonstrating that prophylactic DPP4 inhibition attenuates ...
Rui Wu, Chen Wang, Hui‐Min Tao, Jin Huang, Wei‐Qin Li, Zhi‐Ning Fan   +5 more
wiley   +1 more source

Stability of Myeloid Cell Phenotype and Function Across a Broad Age Range in Humans and Cynomolgus Monkeys, and a Dominant Contribution of Humoral Factors in the Control of Bacterial Infection

Biomedicines
Background: Immune aging is a complex process involving various cellular changes, such as a myeloid bias, decreased functional activity of immune cells, accumulation of senescent cells, and alterations in serum levels of bactericidal humoral factors.
Elena V. Lysakova, Marina Y. Burak, Ilya Larin, Sergey A. Chuvpilo, Viktor S. Laktyushkin, Alexander N. Shumeev, Igor E. Pismennyi, Vladimir Y. Toshchakov, Mikhail Y. Bobrov, Stanislav A. Rybtsov   +9 more
doaj   +1 more source

Repeated instillations of bleomycin in male mice induce a perivascular remodeling at distance of fibrotic areas in the context of progressive pulmonary fibrosis

Animal Models and Experimental Medicine, EarlyView.
We established a model of progressive pulmonary fibrosis via repeated intratracheal instillation (ITI) of leomycin (BLM) (A). Perivascular remodeling was observed in areas distant from the fibrotic areas and lesions induced by repeated ITI of BLM simulate those observed in IPF patients (B). Thus, this model has the capacity to track and investigate the
Céline‐Hivda Yegen, Zakaria Maakoul, Dominique Marchant, Patrice Callard, Julia Bourse, Jean‐François Bernaudin, Hilario Nunes, Carole Planès, Emilie Boncoeur, Nicolas Voituron   +9 more
wiley   +1 more source

Identification of accelerated regions associated with extended post-reproductive lifespan in toothed whales

Frontiers in Ecology and Evolution
An extended female post-reproductive lifespan (PRLS) represents an evolutionary paradox and a rare life-history adaptation in mammals. The molecular mechanisms and genetic changes underlying this trait remain poorly understood.
Nelli A. Arakelyan, Andrey D. Manakhov, Andrey D. Manakhov, Gelena V. Izotova, Maria N. Abramova, Evgeny I. Rogaev, Evgeny I. Rogaev   +6 more
doaj   +1 more source

Discussion corner “Sport in the Modern World” within the framework of the World Youth Festival (March 2, 2024, Sochi, Sirius) [PDF]

Физическое воспитание и студенческий спорт
The article presents a report on the discussion corner “Sport in the modern world” held by the Russian Student Sports Union within the framework of the World Youth Festival.
Eremina, Ekaterina A., Nikitina, Vladislava A., Sterlikova, Veronika Y., Storozhenko, Yulia M.   +3 more
doaj   +1 more source

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

Neurosensory Integration and Balance Adaptation: Personalization of Postural Control Through the Prism of Individual Spatial Perception

Life
Postural control is a multilevel adaptive system that stabilizes the body in space through dynamic sensory rebalancing and predictive neuromotor regulation.
Maxim Baltin, Margarita Nikulina, Diana Sabirova, Tatyana Baltina   +3 more
doaj   +1 more source

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

Pharmaceuticals
Obesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the ...
Stanislav Boychenko, Vera S. Egorova, Andrew Brovin, Alexander D. Egorov   +3 more
doaj   +1 more source

A comprehensive analysis of the use of nucleoside analogues in RNA therapeutics

Journal of Translational Medicine
Background mRNA therapeutics represent a promising frontier in the development of vaccines, anti-cancer treatments, and gene replacement therapies. The mRNA platform facilitates the rapid design of effective and safe candidates.
Alisa A. Kukushkina-Zvezdova, Anna A. Zherebtsova, Darya V. Telegina, Ivan A. Skvortsov, Roman A. Ivanov, Vasiliy V. Reshetnikov   +5 more
doaj   +1 more source