Results 61 to 70 of about 39,633 (292)

Visualization of Multichannel Surface Electromyography as a Map of Muscle Component Activation

Biology and Life Sciences Forum
The study of muscle activation patterns using surface electromyography (sEMG) provides critical insights into muscle coordination, enabling advancements in prosthetics, robotics, and rehabilitation by improving intuitive control, replicating human ...
Alisa E. Pozdnyakova, Galina K. Savon, Leleko P. Lev, Maxim E. Baltin, Yan R. Bravyy, Dmitriy A. Onishchenko   +5 more
doaj   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Biomimetic nanoparticles in cancer photodynamic therapy: a review of targeted delivery systems and therapeutic outcomes

Beilstein Journal of Nanotechnology
Photodynamic therapy (PDT) is a minimally invasive cancer treatment that uses photosensitizers (PSs) activated by light to produce cytotoxic reactive oxygen species (ROS).
Valentina I. Gorbacheva, Alexey S. Grabovoy, Polina S. Marukhina, Anastasiia O. Syrocheva, Ekaterina P. Kolesova   +4 more
doaj   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

Repeatability and agreement of two scheimpflug-based imaging systems for anterior segment parameters in keratoconus

Journal of the Egyptian Ophthalmological Society
Purpose To assess the agreement between the Pentacam HR and the Sirius Scheimpflug analyzer in the anterior chamber, topographic, and corneal aberration parameters and to assess the repeatability of the measurements of each device in patients with ...
Doaa M. Ashour, Hesham M. Gharieb, Nesrin S. Madkour, Ihab S. Othman   +3 more
doaj   +1 more source

Policy recommendations:Covid-19 and labour migration in Denmark

, 2021
The Sirius Danish team (Prof. Michelle Pace and Ms Katrine Sofie Bruun Bennetzen) issued a new report to provide an overview of the main findings of the SIRIUS project in a Danish context.
Pace, Michelle; id_orcid, Bennetzen, Katrine Sofie Bruun   +1 more
core   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Dynamics of Electrical Sensitivity of the Retina and Electrical Lability of the Optic Nerve in the 12-month International Experiment SIRIUS-23

Oftalʹmologiâ
The aim of the 12-month international experiment SIRIUS 23/24 was to evaluate the effects of long-term isolation conditions and exposure to stress factors on electrical sensitivity (ES) of the retina and electrical lability (EL) of the optic nerve (ON ...
V. V. Neroev, M. V. Zueva, V. I. Kotelin, O. M. Man’ko, I. V. Egorova, I. V. Aleskerov, D. V. Fadeev, D. Yu. Kolesnikov   +7 more
doaj   +1 more source

Nuciferine Suppresses Inflammatory Hepatocarcinogenesis by Targeting cPLA2‐Dependent Arachidonic Acid Metabolism

Advanced Science, EarlyView.
Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun, Xinyan Wu, Shuwei Luo, Yilang Liu, Jie Liu, Jun Lu, Weimin Wang, Xiao Feng, Tuo Zhang, Dipak Panigrahy, Jianjun Deng, Xiaojun Liao, Haixia Yang   +12 more
wiley   +1 more source