Results 261 to 270 of about 528,585 (356)

Progress in siRNA therapy and delivery platforms for osteoarthritis. [PDF]

iScience
Song S, Liu W, Wang S, Guo N, Li M, Xie J, Luo X, Yan X, Xu B, Xu Y.   +9 more
europepmc   +1 more source

细胞内氯通道4基因siRNA表达载体的构建及其沉默效应

, 2009
袁兆新, 康劲松, 孔晓霞, 张宏宇, 李洪岩, 郑花, 张勇, 苏静, 孙连坤   +8 more
openalex   +1 more source

43 siRNA based TLR7/8 activation, MHC class I recycling from endosome and cross presentation of HIV-1 antigen for elevated CD8+ response: an approach for intracellular vaccine

, 2016
Anurag Adhikari, Birendra Prasad Gupta
openalex   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Ribosome transfer via tunnelling nanotubes rescues protein synthesis in pancreatic cancer cells. [PDF]

Cell Commun Signal
Martínková S, Jansová D, Vorel J, Lamačová LJ, Daniel P, Hudec M, Boďo M, Hajer J, Susor A, Trnka J.   +9 more
europepmc   +1 more source

Effect of siRNA Targeted against Bcl-x_L on Cell Proliferation and Apoptosis of Prostate Cancer Cells

, 2011
Zhitu Zhu
openalex   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

An Engineered Extracellular Vesicle With Enhanced Tumor and Lymph Nodes Targeting as siRNA Delivery System for Robust Tumor Immunotherapy. [PDF]

MedComm (2020)
Wang Y, Zhang R, Zhou X, Tang L, Hu D, Zhang Y, Yang Y, Zhou B, Yang L.   +8 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source