Results 241 to 250 of about 411,726 (313)

From rules to foundation models: a comprehensive review of machine learning approaches for siRNA design. [PDF]

NAR Genom Bioinform
Khodagholi Z, Yousefi N.
europepmc   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

siRNA did not fail in cancer. It was given the wrong job. [PDF]

Mol Ther Nucleic Acids
Schrand B.
europepmc   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

An EGFR-Targeted Fusogenic Tandem Peptide for siRNA Delivery in Glioblastoma. [PDF]

Pharmaceutics
Boulos JR, Russi KE, Kinnitt J, Gomez Escudero D, Willis T, Abadeer J, Mann E, Anderson AC, Alexander-Bryant A.   +8 more
europepmc   +1 more source

Brain-Targeting siRNA Delivery to Tackle Alzheimer's Disease. [PDF]

Wiley Interdiscip Rev Nanomed Nanobiotechnol
Yang Q, Chen Z, Zhu J, Chai T, Tang F, Fan M, Li Y, Chen S, Liu Y, Zheng M.   +9 more
europepmc   +1 more source

Ultrasound‑responsive nano‑contrast agents co‑delivering CIITA ‑siRNA and rapamycin for targeted therapy against Hashimoto thyroiditis. [PDF]

Chin Med J (Engl)
Zhou X, Guo L, Shi D, Shang M, Sun X, Zhao Y, Wang X, Meng D, Xiao S, Li J.   +9 more
europepmc   +1 more source

Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody-Oligonucleotide Conjugates with High Drug-to-Antibody Ratios. [PDF]

J Med Chem
Cochran M, Nallagatla S, Iacono GD, Abdulkadir S, Arias D, Jordan M, Kwon HW, Levin A, Hood M, Kovach P, Kim A, Burke R, Malecova B, Doppalapudi VR.   +13 more
europepmc   +1 more source

Transport of cytotoxic cyanine dyes coupled to siRNA into hematopoietic cancer cells with CD20-, CD22- or CD33-targeting ELART nanocarriers. [PDF]

Sci Rep
Krassuski T, Bäumer N, Niland S, Grunert K, Wittmann L, Eble JA, Lenz G, Berdel WE, Bäumer S.   +8 more
europepmc   +1 more source