Results 221 to 230 of about 528,585 (356)

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

In vivo self-assembled SOD1-siRNAs mitigate muscle atrophy and denervation in amyotrophic lateral sclerosis. [PDF]

Brain
Guo J, Zou Q, Xu J, Lei J, Yin X, Li B, Fu J, Mi J, Wang Y, Huang H, Zhang CY, Chen X.   +11 more
europepmc   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Polysaccharide-functionalized gold, silver, and iron oxide nanoparticles for siRNA delivery: The role of artificial intelligence in design and optimization. [PDF]

Mater Today Bio
Esmaeilpour D, Sivakumar PM, Khosravi A, Zarepour A, Taj MB, Zare EN, Sillanpaa M, Karimi-Maleh H.   +7 more
europepmc   +1 more source

Lentiviral-mediated delivery of siRNAs for antiviral therapy [PDF]

, 2006
Kevin V. Morris, John J. Rossi
openalex   +1 more source

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Synergistic nanomedicine overcomes hypoxia-driven DNA repair to potentiate radiotherapy for lung adenocarcinoma. [PDF]

Theranostics
Liu Z, Qiu Y, Chen J, Li J, Zhuang C, Feng Q, Huang J, Xiao C, Zheng X, Luo K, Xiao K.   +10 more
europepmc   +1 more source

Systemic and Local Delivery of siRNA to the CNS and Periphery via Anti-IGF1R Antibody Conjugation [PDF]

Mengnan Tian, Mehran Nikan, Miran Yoo, Stephanie Klein, Seung-Hwan Kwon, John Matson, Dongin Kim, Jinwon Jung, Sumin Hyeon, Byeong Min Yoo, H. Park, Michael Tanowitz, Asa Wahlander, Weon-Kyoo You, Hakju Kwon, Janel Huffman, Thazha P Prakash, S. Lee, Hien Zhao, Sungwon An   +19 more
openalex   +1 more source

siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster [PDF]

, 2014
Debashish U. Menon, Cristian Coarfa, Weimin Xiao, Preethi H. Gunaratne, Victoria H. Meller   +4 more
openalex   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source