Results 201 to 210 of about 528,585 (356)

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Small-scale siRNA screen reveals WWC2 as a novel regulator of cardiomyocyte mitosis

Doğacan Yücel, Calvin C. Smith, Natália Ferreira de Araújo, Fernando Souza-Neto, Upendra Chalise, G. Schuler, Bayardo I. Garay, Jennifer Mikkila, Omar Atef Abdelhamid Mahmoud, Pratima Mandal, Rita C. R. Perlingeiro, Jop H. van Berlo   +11 more
openalex   +2 more sources

Cyclam-Modified Polyethyleneimine for Simultaneous TGFβ siRNA Delivery and CXCR4 Inhibition for the Treatment of CCl4-Induced Liver Fibrosis [Corrigendum]

, 2021
Arif Ullah, G Chen, Arshad Hussain, Hamza Khan, Amer Saad Abbas, Z Zhou, M Shafiq, S Ahmad, Ali U, M Usman, F Raza, A Ahmed, Qiu Z, M Zheng, Liu D   +14 more
openalex   +1 more source

Drug Delivery: Lipid‐Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery (Adv. Mater. 33/2013) [PDF]

, 2013
Yunlong Zhang, Jeisa M. Pelet, Daniel A. Heller, Yizhou Dong, Delai Chen, Zhen Gu, Brian Joseph, Jasmine Wallas, Daniel G. Anderson   +8 more
openalex   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Preparation and Antitumor Activity of METTL3 SiRNA Nanoparticles Carried by Hypoxia Sensitive Polymer (mPEG-Azo-PEI). [PDF]

Int J Nanomedicine
Yin Z, Meng Z, Chen B, Wang J, Zhang A, Shen Y, Tang X, Lin S.   +7 more
europepmc   +1 more source

Current siRNA targets in atherosclerosis and aortic aneurysm.

, 2014
Leena Pradhan‐Nabzdyk, Chenyu Huang, Frank W. LoGerfo, Christoph S. Nabzdyk   +3 more
openalex  

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Targeted intracellular oral RNA delivery through tea polyphenol nanovesicle to outer membrane vesicle transfer for colitis treatment. [PDF]

Sci Adv
Fang T, Liu S.
europepmc   +1 more source

Combinatorial Libraries Of Polymeric Vectors For Sirna Delivery: Synthesis, Characterization And In Vitro Evaluation

, 2011
Jeisa M. Pelet
openalex   +1 more source