Robust loading and delivery of functional small RNAs <i>via</i> protein N-myristoylation-induced small extracellular vesicles. [PDF]
Bioact MaterWang H +9 more
europepmc +1 more source
Development of Quantitative Molecular Clinical End Points for siRNA Clinical Trials [PDF]
, 2010 Robyn P. Hickerson +9 more
openalex +1 more source
Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery
, 2023 Mrigank Rai
openalex +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Functional siRNA Delivery via Jet Nebulization: Proof-of-Concept IL-1ß Silencing in Macrophage-like THP-1 Cells. [PDF]
Int J Mol SciNguyen DBT +6 more
europepmc +1 more source
β‐Triketone‐Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery
Advanced Science, EarlyView.This study innovatively applies β‐triketone‐based click chemistry in the synthesis of ionizable cationic lipids (ICLs), which allows the generation of a lipid library in large quantities and in a short time. The ICLs identified achieved effective lipid nanoparticles‐mediated hepatic gene silencing in vivo using siRNA, and computational simulations are ...
Huatian Li +7 more
wiley +1 more source
DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles. [PDF]
ACS NanoWang F +13 more
europepmc +1 more source
Fig4D. Effects of NOX1 siRNA (10 nmol/l) on HG-induced changes in various protein levels in HAECs
, 2021 Yao Li
openalex +1 more source