Results 211 to 220 of about 317,404 (266)
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Trends in Pharmacological Sciences, 2004
The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic mammalian cells has provided researchers with a novel tool to block the expression of disease-causing genes, provided that their mRNA sequences are known. siRNAs can be delivered to cells either exogenously as synthetic agents or endogenously as gene-encoding siRNAs ...
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The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic mammalian cells has provided researchers with a novel tool to block the expression of disease-causing genes, provided that their mRNA sequences are known. siRNAs can be delivered to cells either exogenously as synthetic agents or endogenously as gene-encoding siRNAs ...
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Molecular and Cellular Endocrinology, 2004
RNA interference (RNAi) represents a mechanism invented by nature to protect the genome. In the past few years the field has emerged at a surprisingly high pace. The underlying molecular mechanism of gene silencing provides us with short interfering RNAs (siRNAs) which allows to target any gene with high specificity and efficiency.
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RNA interference (RNAi) represents a mechanism invented by nature to protect the genome. In the past few years the field has emerged at a surprisingly high pace. The underlying molecular mechanism of gene silencing provides us with short interfering RNAs (siRNAs) which allows to target any gene with high specificity and efficiency.
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Chitosan/siRNA Nanoparticles Encapsulated in PLGA Nanofibers for siRNA Delivery
ACS Nano, 2012Composite nanofibers of biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning. Acidic/alkaline hydrolysis and a bulk/surface degradation mechanism were investigated in order to achieve an optimized release profile for prolonged and efficient gene silencing.
Chen, Menglin; id_orcid 0000-0002-2721-651X +7 more
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Oligonucleotides, 2009
Canonical small interfering RNA (siRNA) duplexes are potent activators of the mammalian innate immune system. The induction of innate immunity by siRNA is dependent on siRNA structure and sequence, method of delivery, and cell type. Synthetic siRNA in delivery vehicles that facilitate cellular uptake can induce high levels of inflammatory cytokines and
Marjorie, Robbins +2 more
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Canonical small interfering RNA (siRNA) duplexes are potent activators of the mammalian innate immune system. The induction of innate immunity by siRNA is dependent on siRNA structure and sequence, method of delivery, and cell type. Synthetic siRNA in delivery vehicles that facilitate cellular uptake can induce high levels of inflammatory cytokines and
Marjorie, Robbins +2 more
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Nanomedicine, 2013
By nature, cancer cells are the toughest cells against any treatment. The various available therapies would be much more effective at much lower dose if siRNA against the therapeutic resistance could be identified and successfully codelivered by nanocarriers such as polymer conjugation, micelles, liposomes, solid lipid nanoparticles, nanohydrogels and ...
Zhao, J., Mi, Y., Feng, S.-S.
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By nature, cancer cells are the toughest cells against any treatment. The various available therapies would be much more effective at much lower dose if siRNA against the therapeutic resistance could be identified and successfully codelivered by nanocarriers such as polymer conjugation, micelles, liposomes, solid lipid nanoparticles, nanohydrogels and ...
Zhao, J., Mi, Y., Feng, S.-S.
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siRNA and Cancer Immunotherapy
Immunotherapy, 2012Immunotherapeutic approaches have been gaining attention in the field of cancer treatment because of their possible ability to eradicate cancer cells as well as metastases by recruiting the host immune system. On the other hand, RNA-based therapeutics with the ability to silence expression of specific targets are currently under clinical investigation ...
Soudeh, Ghafouri-Fard +1 more
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Drug Discovery Today: Technologies, 2010
siRNA technology has not only greatly facilitated functional characterization of new genes, but also presented tremendous potential for becoming the next generation of blockbuster drugs. The technology has penetrated life science research in an extremely fast speed, thus providing a huge knowledge base for siRNA drug development.
Xiaoxia Wang +3 more
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siRNA technology has not only greatly facilitated functional characterization of new genes, but also presented tremendous potential for becoming the next generation of blockbuster drugs. The technology has penetrated life science research in an extremely fast speed, thus providing a huge knowledge base for siRNA drug development.
Xiaoxia Wang +3 more
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Imaging of Electrotransferred siRNA
2016SiRNA delivery to the cytoplasm can be obtained through the application of calibrated electric field pulses to a mixture of cells and oligonucleotides. To investigate the uptake pathway, time lapse confocal fluorescence microscopy provides a direct visualization of the transfer.
Muriel, Golzio, Justin, Teissié
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Nature Methods, 2006
A new study addresses how to design highly specific small interfering RNAs (siRNAs) capable of distinguishing between similar variants of the same gene.
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A new study addresses how to design highly specific small interfering RNAs (siRNAs) capable of distinguishing between similar variants of the same gene.
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