Results 291 to 300 of about 528,585 (356)

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Correction to: Significance of targeting DNMT3A mutations in AML. [PDF]

Ann Hematol
Huang G, Cai X, Li D.
europepmc   +1 more source

Myc and Skp2 overexpression promotes p27 ubiquitination and degradation in Ewing Sarcoma. [PDF]

PLoS One
Kubota Y, Kawano M, Itonaga I, Kaku N, Tanaka K.   +4 more
europepmc   +1 more source

Therapeutic potential of siRNA PMP22-SQ nanoparticles for Charcot-Marie-Tooth 1A neuropathy in rodents and non-human primates

Liliane Massaad-Massade
openalex   +1 more source

Protocol to investigate the effects of localized gene expression disruption on mouse limb development via direct siRNA injection and explant culture. [PDF]

STAR Protoc
Yea JH, Onggo SES, Dewagan S, Chen K, Young KK, Cahan P.   +5 more
europepmc   +1 more source

Targeting CDH13 as a therapeutic strategy to mitigate pathological ocular angiogenesis. [PDF]

J Transl Med
Yin W, Xu M, Niu Z, Gao Y, Su N, Song Y, Liu Q.   +6 more
europepmc   +1 more source

Programmable Lipid Functionalization of Nucleic Acid Nanoparticles Modulates Liver Cell-Type Targeting. [PDF]

ACS Appl Mater Interfaces
Kim HM, Omer M, Knappe GA, McMullen P, Le DA, Pasupathy A, Anderson DG, Bathe M.   +7 more
europepmc   +1 more source

Antitumor effect of hyaluronic-acid-modified chitosan nanoparticles loaded with siRNA for targeted therapy for non-small cell lung cancer

, 2019
Weiyi Zhang, Xu Wang, Lan Y, X. T. He, Kun Liu, Yongwei Liang   +5 more
openalex   +1 more source

Nanoparticle based siRNA therapeutics for ovarian cancer overcoming drug resistance and future directions. [PDF]

Discov Nano
Di Fonte R, Bolognino I, Sommonte F, Serratì S, Fasano R, Arduino I, Iacobazzi RM, Denora N, Perego P, Rossi G, Tosi D, Porcelli L, Azzariti A.   +12 more
europepmc   +1 more source