Results 301 to 310 of about 528,585 (356)
Some of the next articles are maybe not open access.
2021
Exosomes are membrane-bound vesicles (40-100 nm) of endocytic origin released by numerous cell types that act as natural carriers of mRNA, microRNA, and proteins between cells. We developed a new system that uses intravenous injection of modified exosomes for siRNA delivery into the brain.
María, Izco, Lydia, Alvarez-Erviti
openaire +2 more sources
Exosomes are membrane-bound vesicles (40-100 nm) of endocytic origin released by numerous cell types that act as natural carriers of mRNA, microRNA, and proteins between cells. We developed a new system that uses intravenous injection of modified exosomes for siRNA delivery into the brain.
María, Izco, Lydia, Alvarez-Erviti
openaire +2 more sources
Trends in Pharmacological Sciences, 2004
The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic mammalian cells has provided researchers with a novel tool to block the expression of disease-causing genes, provided that their mRNA sequences are known. siRNAs can be delivered to cells either exogenously as synthetic agents or endogenously as gene-encoding siRNAs ...
openaire +2 more sources
The ability of small-interfering RNAs (siRNAs) to silence gene expression in somatic mammalian cells has provided researchers with a novel tool to block the expression of disease-causing genes, provided that their mRNA sequences are known. siRNAs can be delivered to cells either exogenously as synthetic agents or endogenously as gene-encoding siRNAs ...
openaire +2 more sources
Molecular and Cellular Endocrinology, 2004
RNA interference (RNAi) represents a mechanism invented by nature to protect the genome. In the past few years the field has emerged at a surprisingly high pace. The underlying molecular mechanism of gene silencing provides us with short interfering RNAs (siRNAs) which allows to target any gene with high specificity and efficiency.
openaire +2 more sources
RNA interference (RNAi) represents a mechanism invented by nature to protect the genome. In the past few years the field has emerged at a surprisingly high pace. The underlying molecular mechanism of gene silencing provides us with short interfering RNAs (siRNAs) which allows to target any gene with high specificity and efficiency.
openaire +2 more sources
Nanomedicine, 2013
By nature, cancer cells are the toughest cells against any treatment. The various available therapies would be much more effective at much lower dose if siRNA against the therapeutic resistance could be identified and successfully codelivered by nanocarriers such as polymer conjugation, micelles, liposomes, solid lipid nanoparticles, nanohydrogels and ...
Zhao, J., Mi, Y., Feng, S.-S.
openaire +2 more sources
By nature, cancer cells are the toughest cells against any treatment. The various available therapies would be much more effective at much lower dose if siRNA against the therapeutic resistance could be identified and successfully codelivered by nanocarriers such as polymer conjugation, micelles, liposomes, solid lipid nanoparticles, nanohydrogels and ...
Zhao, J., Mi, Y., Feng, S.-S.
openaire +2 more sources
2004
RNA interference is the process that double-stranded RNA (dsRNA) induces the homology-dependent degradation of cognate mRNA mediated by 21- to 23-nt small interfering RNA (siRNA). Successful application of RNAi in functional genomics and proteomics, cancer gene therapy, and virus protection depends on the efficient delivery of siRNA into mammalian ...
Changxian, Shen, Sven N, Reske
openaire +2 more sources
RNA interference is the process that double-stranded RNA (dsRNA) induces the homology-dependent degradation of cognate mRNA mediated by 21- to 23-nt small interfering RNA (siRNA). Successful application of RNAi in functional genomics and proteomics, cancer gene therapy, and virus protection depends on the efficient delivery of siRNA into mammalian ...
Changxian, Shen, Sven N, Reske
openaire +2 more sources
2009
With the recent discovery of small interfering RNA (siRNA), to silence the expression of genes in vitro and in vivo, there has been a need to deliver these molecules to the cell nucleus. Forming a lipid/nucleic acid complex has become a solution and is explored here.
Jeffrey, Hughes +2 more
openaire +2 more sources
With the recent discovery of small interfering RNA (siRNA), to silence the expression of genes in vitro and in vivo, there has been a need to deliver these molecules to the cell nucleus. Forming a lipid/nucleic acid complex has become a solution and is explored here.
Jeffrey, Hughes +2 more
openaire +2 more sources
PLGA Microspheres Encapsulating siRNA
2014The therapeutic use of small interfering RNA (siRNA) represents a new and powerful approach to suppress the expression of pathologically genes. However, biopharmaceutical drawbacks, such as short half-life, poor cellular uptake, and unspecific distribution into the body, hamper the development of siRNA-based therapeutics.
DE ROSA, GIUSEPPE, SALZANO, GIUSEPPINA
openaire +3 more sources
Chitosan/siRNA Nanoparticles Encapsulated in PLGA Nanofibers for siRNA Delivery
ACS Nano, 2012Composite nanofibers of biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning. Acidic/alkaline hydrolysis and a bulk/surface degradation mechanism were investigated in order to achieve an optimized release profile for prolonged and efficient gene silencing.
Chen, Menglin +7 more
openaire +2 more sources