Results 21 to 30 of about 62,260 (164)

Impact of prenatal sirolimus on cardiac rhabdomyomas and brain tubers. [PDF]

Ultrasound Obstet Gynecol
ABSTRACT Objective To document the natural progression of fetal cardiac rhabdomyomas and evaluate the impact of prenatal sirolimus (PNS) on tumor size, cardiac complications and brain‐tuber size. Methods This was a single‐center retrospective cohort study of pregnancies with suspected fetal cardiac rhabdomyoma referred to our center from April 2013 to ...
Vergote S, Van der Veeken L, Chitayat D, Jaeggi E, Ryan G, Miller E, Shinar S.   +6 more
europepmc   +2 more sources

Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients

Journal of Lipid Research, 2002
Sirolimus (Rapammune®, rapamycin, RAPA) is a potent immunosuppressive drug that reduces renal transplant rejection. Hyperlipidemia is a significant side effect of sirolimus treatment, and frequently leads to cardiovascular disease.
Joel D. Morrisett, Ghada Abdel-Fattah, Ron Hoogeveen, Eddie Mitchell, Christie M. Ballantyne, Henry J. Pownall, Antone R. Opekun, Jonathon S. Jaffe, Suzanne Oppermann, Barry D. Kahan   +9 more
doaj   +1 more source

Avaliação da endotelização de hastes de stents em artérias ilíacas de coelhos Assessment of stent strut endothelialization in iliac arteries of rabbits

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: A rápida endotelização pós-implante de stent é ocorrência desejável por teoricamente reduzir a possibilidade de trombose do stent. OBJETIVO: Avaliar a extensão da endotelização de hastes de stents eluidores de sirolimus (liberados da face ...
Celso Kiyochi Takimura, Ii-sei Watanabe, Francisco Rafael Martins Laurindo, Paulo Sampaio Gutierrez, Vera Demarchi Aiello, Spero Penha Morato, Pedro Alves Lemos Neto   +6 more
doaj   +3 more sources

Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex

Frontiers in Pharmacology, 2021
The purposes of this study were to explore the population pharmacokinetics and initial dose optimization of sirolimus improving drug blood level for seizure control in pediatric patients with tuberous sclerosis complex (TSC).
Xiao Chen, Dongdong Wang, Lin Zhu, Jinmiao Lu, Yidie Huang, Guangfei Wang, Yiqing Zhu, Qiaofeng Ye, Yi Wang, Hong Xu, Zhiping Li   +10 more
doaj   +1 more source

mTOR inhibitor reduces nontumour-related death in liver transplantation for hepatocellular carcinoma

Molecular Biomedicine
Sirolimus is a regularly applied immunosuppressant for patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). Sirolimus not only significantly inhibits HCC recurrence but also protects renal function.
Lincheng Zhang, Peng Liu, Li Zhuang, Sunbin Ling, Qifan Zhan, Wei Zhou, Renyi Su, Lu Yin, Qingyang Que, Jiachen Hong, Jiaqi Bao, Chuxiao Shao, Jinzhen Cai, Shusen Zheng, Xiao Xu   +14 more
doaj   +1 more source

Acute sirolimus overdose: a multicenter case series. [PDF]

PLoS ONE, 2015
There are few data relating to sirolimus overdose in the medical literature. Our objectives were to describe all cases of overdose with sirolimus reported to Swiss, German and Austrian Poisons Centres between 2002-2013.An observational case-series ...
Alessandro Ceschi, Elja Heistermann, Sonja Gros, Cornelia Reichert, Hugo Kupferschmidt, Nicholas R Banner, Stephan Krähenbühl, Anne B Taegtmeyer   +7 more
doaj   +1 more source

Optimization of Initial Dose Regimen for Sirolimus in Pediatric Patients With Lymphangioma

Frontiers in Pharmacology, 2021
Sirolimus is an effective oral treatment for pediatric patients with lymphangioma. The present clinical study in 15 children (0.12–16.39 years of age) examines the effects of underlying factors on sirolimus concentrations through application of a ...
Xiao Chen, Dongdong Wang, Guangfei Wang, Yidie Huang, Xin Yu, Jinmiao Lu, Xiaowen Zhai, Hong Xu, Zhiping Li   +8 more
doaj   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

The use of sirolimus in patients with recurrent cytomegalovirus infection after kidney transplantation: A retrospective case series analysis

Saudi Journal of Kidney Diseases and Transplantation, 2019
Cytomegalovirus (CMV) is one of opportunistic infections post solid organ transplant and remains a cause of morbidity and mortality. Mammalian target of rapamycin inhibitors has a theoretical antiviral advantage compared to conventional immunosuppression.
Ali M Shendi, Rachel K. Y Hung, Ben Caplin, Paul Griffiths, Mark Harber   +4 more
doaj   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source