Results 31 to 40 of about 117,553 (304)

Reduced risk of recurrent pneumothorax for sirolimus therapy after surgical pleural covering of entire lung in lymphangioleiomyomatosis

Orphanet Journal of Rare Diseases, 2021
Background Patients with lymphangioleiomyomatosis (LAM) frequently experience pneumothorax. Although sirolimus is the standard therapy for LAM, its effect on pneumothorax is controversial.
Teiko Sakurai, Toru Arai, Masaki Hirose, Kensuke Kojima, Tetsuki Sakamoto, Yoshinobu Matsuda, Chikatoshi Sugimoto, Hyung-Eun Yoon, Yoshikazu Inoue   +8 more
doaj   +1 more source

Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs

Clinical Cancer Research, 2021
Purpose: The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition of mTOR signaling is biologically achievable with sirolimus, and might slow the outgrowth of ...
A. LeBlanc, C. Mazcko, Aswini Cherukuri, E. Berger, W. Kisseberth, Megan E Brown, S. Lana, K. Weishaar, B. Flesner, J. Bryan, D. Vail, J. Burton, J. Willcox, A. Mutsaers, J. P. Woods, N. Northrup, C. Saba, K. Curran, H. Leeper, H. Wilson-Robles, Brandan G. Wustefeld-Janssens, Stephanie E. S. Lindley, Annette N Smith, N. Dervisis, S. Klahn, M. L. Higginbotham, R. Wouda, E. Krick, J. Mahoney, C. London, L. Barber, C. Balkman, Angela L. McCleary‐Wheeler, S. Suter, O. Martin, A. Borgatti, K. Burgess, M. Childress, J. Fidel, S. Allstadt, D. Gustafson, L. Selmic, C. Khanna, T. Fan   +43 more
semanticscholar   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Enhanced Supersaturation and Oral Absorption of Sirolimus Using an Amorphous Solid Dispersion Based on Eudragit® E

Molecules, 2015
The present study aimed to investigate the effect of Eudragit® E/HCl (E-SD) on the degradation of sirolimus in simulated gastric fluid (pH 1.2) and to develop a new oral formulation of sirolimus using E-SD solid dispersions to enhance oral ...
Youngseok Cho, Eun-Sol Ha, In-Hwan Baek, Min-Soo Kim, Cheong-Weon Cho, Sung-Joo Hwang   +5 more
doaj   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Pharmacokinetic analysis after implantation of everolimus-eluting self-expanding stents in the peripheral vasculature [PDF]

, 2012
Background: A novel self-expanding drug-eluting stent was designed to release everolimus 225 mu g/cm(2) to prevent restenosis following peripheral arterial intervention.
Hausegger, Klaus A, Koppensteiner, Renate, Lammer, Johannes, Mellon, Rajeev M, Scheinert, Dierk, Schroë, Herman, Schwartz, Lewis B, Vermassen, Frank   +7 more
core   +2 more sources

Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel [PDF]

, 2020
No biomarker panel is established for prediction of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD), a major complication of allogeneic stem cell transplantation (alloSCT).
Blau, Igor W., Bullinger, Lars, Dreger, Peter, Jiang, Sihe, Luft, Thomas, Majer-Lauterbach, Joshua, Müller-Tidow, Carsten, Penack, Olaf, Radujkovic, Aleksandar, Schult, David, Terzer, Tobias   +10 more
core   +3 more sources

Oral and Topical Sirolimus for Vascular Anomalies: A Multicentre Study and Review

Acta Dermato-Venereologica, 2019
Vascular anomalies (VAs) may be associated with significant morbidity and mortality. The aim of this study was to evaluate the efficacy and safety of sirolimus (rapamycin) in the treatment of children and young adults with complicated VAs.
Shira Sandbank, Vered Molho-Pessach, Adam Farkas, Aviv Barzilai, Shoshana Greenberger   +4 more
doaj   +1 more source

Implantation of paclitaxel-eluting stents in saphenous vein grafts: clinical and angiographic follow-up results from a multicentre study. [PDF]

, 2006
Objective: To define the clinical and angiographic follow-up results after implantation of paclitaxel-eluting stents (PESs) in stenotic saphenous vein grafts (SVGs). Design: Prospective multicentre study. Comparison with a control group.
Blindt, Ruediger, Boeckstegers, Peter, Heitzer, Thomas, Hoffmann, Rainer, Köster, Ralf, Pohl, Tilmann   +5 more
core   +2 more sources

Sirolimus in the treatment of kaposiform lymphangiomatosis

Orphanet Journal of Rare Diseases, 2021
Background Kaposiform lymphangiomatosis (KLA), which is a new subtype of generalized lymphatic anomaly, is a rare disease with a poor prognosis. Currently, there is no standard treatment due to the poor understanding of KLA.
Jiangyuan Zhou, Kaiying Yang, Siyuan Chen, Yi Ji   +3 more
semanticscholar   +1 more source