Results 1 to 10 of about 10,371 (142)

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2019
Background Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα ...
Jiao Wu, Jiangling Dong, Daniela Verzola, Keith Hruska, Giacomo Garibotto, Zhaoyong Hu, William E. Mitch, Sandhya S. Thomas   +7 more
doaj   +3 more sources

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes [PDF]

Journal of Neuroinflammation, 2011
Background Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops.
Reichert Fanny, Oldenborg Per-Arne, Liraz-Zaltsman Sigal, Gitik Miri, Rotshenker Shlomo   +4 more
doaj   +4 more sources

Phagocytic receptors activate and immune inhibitory receptor SIRPalpha inhibits phagocytosis through paxillin and cofilin [PDF]

Frontiers in Cellular Neuroscience, 2014
The innate-immune function of phagocytosis of apoptotic cells, tissue-debris, pathogens and cancer cells is essential for homeostasis, tissue repair, fighting infection and combating malignancy.
Miri eGitik, Rachel eKleinhaus, Smadar eHadas, Fanny eReichert, Shlomo eRotshenker, Shlomo eRotshenker   +5 more
doaj   +3 more sources

Deciphering the role of signal regulatory protein α in immunotherapy for solid tumors [PDF]

Frontiers in Immunology
Therapies targeting immune checkpoints like programmed death receptor-1 and programmed death ligand-1 have demonstrated remarkable effectiveness in combating cancer.
Yulong Zhou, Xiyang Tang, Weiguang Du, Chen Shu, Chen Shu, Xiaolong Yan, Nan Ma, Jinbo Zhao   +7 more
doaj   +2 more sources

SIRPα blockade therapy potentiates immunotherapy by inhibiting PD-L1+ myeloid cells in hepatocellular carcinoma [PDF]

Cell Death and Disease
Tumor-infiltrating myeloid cells (TIMs) are pivotal cell populations involved in the immunosuppressive tumor immune microenvironment (TIME). However, there has been little success in large-scale clinical trials of myeloid cell modulators.
Da Huang, Min Xu, Hui Wang, Yufei Zhao, Zihao Zhang, Mincheng Yu, Mingqin Zhou, Jingying Pan, Hong Zeng, Zichuan Yu, Qiang Yu, Mengyuan Wu, Wenxin Xu, Binghai Zhou, Bo Zhang, Hui Li, Lei Guo, Peiyi Xie   +17 more
doaj   +2 more sources

SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis

EBioMedicine, 2022
Summary: Background: To determine whether SIRPα can be a diagnostic marker of pulmonary tuberculosis (PTB) and the molecular mechanism of SIRPα regulating macrophages to kill Mycobacterium tuberculosis (MTB).
Di Wang, Yunkai Lin, Feihong Xu, Hui Zhang, Xiaoyan Zhu, Zhen Liu, Yuan Hu, Guanjun Dong, Bingqi Sun, Yanhong Yu, Guoren Ma, Zhigang Tang, Diana Legarda, Adrian Ting, Yuan Liu, Jia Hou, Liwei Dong, Huabao Xiong   +17 more
doaj   +1 more source

Leishmania Infection-Induced Proteolytic Processing of SIRPα in Macrophages

Pathogens, 2023
The shedding of cell surface receptors may bring synergistic outcomes through the loss of receptor-mediated cell signaling and competitive binding of the shed soluble receptor to its ligand.
Hana Hirai, Jing Hong, Wataru Fujii, Chizu Sanjoba, Yasuyuki Goto   +4 more
doaj   +1 more source

Mouse conventional dendritic cells can be universally classified based on the mutually exclusive expression of XCR1 and SIRPα [PDF]

Frontiers in Immunology, 2014
Since the identification of mouse dendritic cells (DC) in the early 70s, all attempts to consistently classify the identified functional DC subpopulations according to their surface molecule expression failed. In the absence of DC lineage markers, a great variety of non-congruent surface molecules were used instead. Recent advances in the understanding
Gurka, Stephanie, Hartung, Evelyn, Becker, Martina, Kroczek, Richard   +3 more
openaire   +4 more sources

Ontogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα [PDF]

Frontiers in Immunology, 2014
In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor XCR1 is a lineage marker for cross-presenting DC in the spleen.
Becker, M, Güttler, S, Bachem, A, Hartung, E, Mora, A, Jäkel, A, Hutloff, A, Henn, V, Mages, HW, Gurka, S, Kroczek, RA   +10 more
openaire   +5 more sources

Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling. [PDF]

PLoS ONE, 2015
Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPα and its ligand CD47 are involved in phagocyte ...
Julian Alvarez-Zarate, Hanke L Matlung, Takashi Matozaki, Taco W Kuijpers, Isabelle Maridonneau-Parini, Timo K van den Berg   +5 more
doaj   +1 more source